Signatera Test. Is it truly helpful and worthwhile?

Posted by pbnew @pbnew, Nov 30, 2023

I haven’t met anyone who has used this test. Do oncologists recommend it? How does it help?

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Profile picture for roseann4z @roseann4z

I have had this test quarterly for two years. My oncologist finds it useful in that it has cut my PET scans down first to every 6 months to now yearly. If I have symptoms or if the test is positive we will do a PET sooner. I find that helps me mentally. My oncologist is concerned about all the radiation from repeated scans over years.

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I am interested in the Signatura testing, as are several friends in my mets group. So far, it is not available (not being offered) to us. Are you receiving care in the US? Any info you can give would be greatly appreciated.

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Every 3 months after metastasis then every 6 months and now, once a year….so 5 or 6. In the big scheme of things, radiation is not a concern.

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Profile picture for texas5 @texas5

I have had 2 pet/ct which definitely worry about radiation exposure.
Since your Onc is worried may I ask how many you have had?

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As someone with recurrences to my lymph nodes & other places over the years, for some time I was being scanned 2-3 times per year for several years. I would guess over the span of the last 10 years I have had at least 12.

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Profile picture for roseann4z @roseann4z

I have had this test quarterly for two years. My oncologist finds it useful in that it has cut my PET scans down first to every 6 months to now yearly. If I have symptoms or if the test is positive we will do a PET sooner. I find that helps me mentally. My oncologist is concerned about all the radiation from repeated scans over years.

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I have had 2 pet/ct which definitely worry about radiation exposure.
Since your Onc is worried may I ask how many you have had?

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Profile picture for casbc @casbc

I have it done every 3 months and my numbers are going down. Started @ 0.92, down to 0.12 now 0.05. On my way to ZERO!

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Congrats....come on ZERO!

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I have it done every 3 months and my numbers are going down. Started @ 0.92, down to 0.12 now 0.05. On my way to ZERO!

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My new oncologist won't order it. I'm possibly going to change insurance I have kaiser.

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I have had this test quarterly for two years. My oncologist finds it useful in that it has cut my PET scans down first to every 6 months to now yearly. If I have symptoms or if the test is positive we will do a PET sooner. I find that helps me mentally. My oncologist is concerned about all the radiation from repeated scans over years.

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Profile picture for mspass @mspass

Anyone doing circulating tumor DNA testing? I just started last week, results in 4-6 wks

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@mspass, I moved your post about circulating tumor DNA testing to this active discussion on the same topic.

- Signatera Test. Is it truly helpful and worthwhile? https://connect.mayoclinic.org/discussion/signatera-test-is-it-truly-helpful-and-worthwhile/

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Anyone doing circulating tumor DNA testing? I just started last week, results in 4-6 wks

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