Rising PSA after seed Implants

Posted by celtic @celtic, 14 hours ago

After seed implants on 12/21/2020.My PSA has gone up to 2.68 what is the best salvage therapy?

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You didn’t just have seeds you had radiation. What kind of radiation? Brachytherapy?

You don’t have Salvage radiation after Radiation. You have salvage radiation if you’ve gotten a prostatectomy.

You need a PSMA pet test to see if there are metastasis that can be zapped. That would be the first thing since your PSA is high. The other thing that’s important is how fast your PSA has been rising the doubling rate. That is what the doctor goes by to figure out what sort of treatment applies.

At this point, you should be on ADT, Unless they are able to zap metastasis that are causing this PSA rise. It could be the PET scan doesn’t find anything, because you’ve got Micro metastasis and they can’t be seen because they are too small. If that happens, then ADT is what they give you plus an ARPI Like Zytiga or one of the lutamides. You need to speak to an oncologist to find out what you should do. A radiation oncologist might be able to handle this to begin with, but you’ve got reoccurrence.

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I’m assuming you had LDR ‘permanent’ seeds placed? What was your PSA before and after treatment? What was your nadir?
How much higher is your current PSA from its measurement at its lowest point, roughly 18 months after treatment?
Phil

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