Rising PSA years after radical prostatectomy

PSA levels change through out the day just like one’s Testosterone levels do! It can depend on what time of the day you test! Obviously, anytime your PSA Levels rise is a time to be watchful and careful. However, I would caution that too many men unnecessarily “freak out” a little if their PSA levels rise even on the most minimal of levels. If they continue to rise then seek the advice of your cancer treatment team and take whatever the next and most appropriate steps are to more specifically determine if anything needs to be followed more closely or if there is any evidence what so ever that any of your cancer has returned, where and to what degree. Remember, once you’ve been diagnosed and treated for cancer it becomes a lifetime of observation and then additional treatments to eradicate it if necessary. As cancer patients, we are responsible along with our health care teams to monitor any significant changes in our situation, react and treat accordingly. As you already know…..There are absolutely NO
GUARANTEES about Cancer. We can all be thankful and rejoice when we are in remission and take the necessary steps required to address our personal situations when we are not! It’s really the best we can do. I’ve coined the following phrase regarding cancer. Please feel free to use or share it with others if it resonates with you.

“Cancer is NEBULOUS at best,
SINISTER at worse and VILLAINOUS in between!”

However, that being said, we do everything we can as patients to manage our cancer the very best we can. We deal with whatever comes our way when and if it comes our way. Hopefully, we continue to be as successful and in remission for as long as we can possibly be.

GOD SPEED

I'm 65 and had my RP in September 2016. PSA was

I am 63 had my prostatectomy in 2014. Had a PSA test in 2021 come back 0.05 had one in 2023 it had gone up to 1.51. Had one two days a go up to 1.79 any thoughts.

Did same then put on Zolodex injections do it

after 4 years they took me off

Cancer metasomatized to L2 which we nuked 1 inch out

now psa climbing again 1.2 4.22 5.23 and 6.6 getting PET and CT scans

loosing c sensitive ?

Sounds like you’re just beginning. I am 13 years in and this is what my journey was like. Lupron injections immediately plus bicalutamide. My Gleason scores were all 10+, very bad. That lasted about four years and then they started me on Zytiga and Lupron. Occasional PSA’s from .1 up to four or five. Now that you’re a 13 I had a PSA rise to 30 and through diet, prayer, and some radiation treatments on bone cancer. It has come back down to 11. I still play golf and I still ride my Harley . And babysit the grandkids, and live alone. But I have much less energy than before. I encourage you to do research now to find a direction that will cure your cancer and not just treat it. I have become cynical and see my doctors and treatment centers as Using me for that insurance payment. None ever speak of a cure, they all speak of treatments. And several doctors have told me directly they are not going to treat other known spaces of cancer in my body until it becomes painful. I question that and have not gotten an answer. Other than that is how we do it . Obviously, you and I do not have access to proactive treatment.

What is the benchmark of PSA value for further treatment after man has gone through radical prostatectomy and combined radiation and hormone therapy. I have been through radical prostatectomy. I am currently on biculatamide 150mg which I started with radiation (25 does) for 5 weeks. he biculatamide is to be taken up to 31st March 2023 (18 months). Currently my PSA is not detectable.

I am yet to contact my urologist on 12th th Dec.

I started with radiation therapy (25 doses) in Sept. 2021 alongside 150mg biculatimide daily. I had radition of the breast and staryed with 150mg a week before the radiation.

PSA values
Dec. 2021 - less than 0.1
Jan, Feb, April, May, Aug, Sept, Oct.
All less than 0.1
I asked the urologist and he said that these values mean psa is not detectable. I am stil on the 150mg and will stop in end of March 2023

I am told Biculatimide is same as Casodex.
There are side effects but I have managed them - decrease in urge for sex and AT TIMES weak erection , constipation, tiredness, pains in my breast and burning sensation on toes, intermittent back and side pains, at times pelvic pains.
I train in the gym 3 - 4 times weekly.

I have been told to check psa twice a year from March 2023 but I have opted for 3 times. I am told the bench mark for further treatment after this is 0.4. I am yet to confirm from the urologist on 12th Dec. Any idea?

I thank all of you for your ideas. This forum has helped me a lot.

Did 40 rads 5 years ago, then Zolodex fot 3 yrs. L2 nuked 1 inch out PSA was 1.2 on Zolodex for 2 years PSA up 4.22, 5.23 and now 6.6 in 4 months
Doing bone scan Monday PET nuclear than CT scan week after. Feel great Weak spine if I stand to long or walk long distance.

What you think I'm stage 4 metastatic castrate sensitive My testosterone levels are <.o4 so Zolodex works, but why PSA up to 6.6? Am I going resistive, then what?

Removed 2009 so 13 years ago yesterday. Now almost 80 years old. 5 years ago PSA slowing rising and went to .72 a year ago slowly over 5 years and Vanderbilt prostate oncologist said just check each 6 mo. Now to 1.02. Still says watch at my age. No symptoms and had scan and he says watch?

Hi, where exactly are they radiating? Did you have a PSMA PET Scan to locate the recurrence?