Reducing Reclast dosage.

Posted by karenjaninaz @karenjaninaz, Jun 6 4:14pm

After 2 doses of Prolia from which I felt unwell I researched the medical literature and found 3 studies which suggested a lower dose of Reclast is as effective as 5 mgm. I sent the articles to my endo and she called me today with the news she is lowering the dose to 4 mgm.
Hopefully I will have less chance of feeling miserable. I am 83 with osteopenia but have been on steroids since 2014 for polymyalgia rheumatica. She and my primary doc are allowing me to take strontium citrate as well plus dietary calcium.
Retired nurse anesthetist .

Interested in more discussions like this? Go to the Osteoporosis & Bone Health Support Group.

When will you have the Reclast infusion? And we would be so grateful if you could share your experience.

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I am soon to finish my 12 month series of Evenity and Reclast is an option for the next medication. Would you be so kind as to share your sources of information regarding the lower dosage as I would love to also read them. Best of luck to you and take care.

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I’m very interested in looking into those sources too. Will likely have Reclast in my future and have been curious about mentions in this forum about the effectiveness of lower doses of Reclast.

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I also have been told to try reclast - but I've asked to remain on Fosomax (taken for a year; a bit better dexa and very little seriously uncomfortable side effects for me). Doc isn't answering me when email if I can start back on Fosamax; we discussed this at a question and answer appointment in May (he was ok with it) when we had an appointment to talk about reclast, which he really wants me to do and scares me to death. I understand that really bad and long lasting side effects are unusual; but many people seem to have life altering problems with it. Would LOVE to try a lower dose; I see twice a year lower doses; a low trial dose to see how your body handles etc. Doubt my doc would be on board with this, so also very interested in anyone who has had any type of lower dose of reclast.

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Can you share a link to the resources you used? Would like to read them. Thanks

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Here is a link to an interesting article regarding reducing recast dosage. https://pmc.ncbi.nlm.nih.gov/articles/PMC4959627/
Intravenous zoledronate for osteoporosis: less might be more
Andrew Grey 1,✉
Author information
Article notes
Copyright and License information
PMCID: PMC4959627 PMID: 27493690

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Here is an additional article re low dosage reclast:
low-dose-reclast-1.pdf
In the 12-month phase II study of zole- dronate, several iv dosing regimens were demonstrated to be equally effective in decreasing markers of bone turn- over and increasing bone mineral density (BMD) (6). In- cluded among the treatments evaluated in that trial were three that involved administration of a total dose of 4 mg administered as a single baseline dose, two doses of 2 mg administered every 6 months, or four doses of 1 mg ad- ministered every 3 months; one that involved administra- tion of a total dose of 2 mg administered as 0.5 mg every 3 months; and one that involved administration of a total dose of 1 mg administered as 0.25 mg every 3 months. However, there are currently no studies that have evalu- ated the antiresorptive effects of annual doses of zoledro- nate below 4 mg.

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Thank you. That’s interesting.

My doctor ordered Zometa which is the same med but comes as 4 mgm.

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@sandrac

Can you share a link to the resources you used? Would like to read them. Thanks

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See below
I am getting Zometa which is the same as Reclast but comes in 4 mgm.

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