reclast and aspirin allergy

It looks like you're new to Connect. WELCOME! I'm glad you found us, and hope that someone here can answer your specific question.

I did find this on drugs.com in the Reclast Prescribing Information: "While not observed in clinical trials with Reclast, there have been reports of bronchoconstriction in aspirin-sensitive patients receiving bisphosphonates. Use Reclast with caution in aspirin-sensitive patients."

When I joined this forum only a few months ago, @rola told me, "Don't just go by the headings [of the posts] bc [sic] there are nuggets in every conversation that are useful." If it weren't for her words, I might not have taken a deep dive. Doing so, I learned so much more than I could have ever imagined. It's a friendly environment full of knowledgable members. With there help, I'm finally getting a good enough grip on things, and I'm ready to start a proper conversation with my doctor when I meet with him later this week.

I'll share some of what I've learned about the drug options that were given to you by your doctor. Even though it doesn't directly address your questions, it may be none-the-less useful.

If you already know the basic mechanisms of how Reclast and Prolia work to improve bone density, you can ignore the rest of this. I'll try not to waft, though that might be difficult for me. 🙂 Actually, I think I'm already wafting. Sorry about that.

If I get something wrong, I hope someone will jump in and make corrections.

Delaying treatment while educating yourself may not be the way you prefer to go. If you feel like you want to get started straight away, here are a couple of things that I personally think are worth considering when comparing the options recommened by your doctor, Reclast and Prolia.

They are both anti-resorpatives (they slow down the breakdown of old bone), but the way in which they do it, is VERY different.

1) Reclast is the name brand for Zolendronic acid. It is one of four different Bisphonates. Of the four, Reclast gives you the biggest dose right up front. For some people, it's too much. Bisphosphonates kill off osteoclasts which are the things that break down bone. This means there are fewer of them, so you lose less bone. You can stop taking it at anytime to change your treatment. When you do so, osteoclastics will slowly build up again. I've heard it said by Dr. R. Keith McCormick (he's sort of the go-to guy for all things OP) that bisphosphonates can be used to "buy you time" while you figure out what's going on and what you want to do. If you choose to go that route, the question to ask is, in your case, which Bisphosphonate would be best.

2) Prolia (Denosumab) treatment is pretty much a lifelong commitment. The longer you're on it, the harder and more dangerous it is to discontinue use. Denosumab suppresses the osteoclasts rather than kill them. If you stop taking the drug, the osteoclasts go on a feeding frenzy, breaking down bone at an accelerated rate.

There's so much more to know and consider. This is just the basics as I understand them on two of the options. There are several more approaches to treatment. Ideally, your doctor will work with you to narrow down the cause of your bone loss, and taylor an individualized plan.

Thank you for your information. I will update after I see another doctor for a 2nd opinion.