Reaction to Tymlos

Posted by annashaffer @annashaffer, Aug 7 12:57pm

I was on Tymlos shots that I gave myself. I got severe muscle and bone pain. My pharmacist said this was a side effect of Tymlos. Opoids given by doctor pain did not help pain. Pharmacist had to call doctor to get her to listen of cause of pain. Tymlos did things to my body, gritty teeth, fingernails soft like paper peeled cracked, calcium in my blood and abnormal blood results and other parts of my body it wasn't suppose to be in. It has taken me over six months trying to get normal labs and body feeling normal. I now am on prolia

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hlp123 | @hlp123 | Aug 10 5:13pm

Has anyone else reacted to tymlos with these side effects ?
I am trying to decide if I should take it or evenity. So hard to decide. I am very vulnerable to side effects. I took Prolia because my doctor told me that it had less side effects than any of the medications. I had severe bone and muscle pain. Anxious to hear your experiences. thank you

hollygs | @hollygs | Aug 11 11:33am

Hi @hlp123. I was on Tymlos for almost a year and did have some side effects, but they weren't severe - fatigue and joint pain. I took Fosamax intermittently and then one year of Evenity prior to Tymlos. I had no discernible side effects from Fosamax and Evenity. I then had my first Reclast infusion in May 2025 and have had no side effects thus far.
Your medical history is a determining factor in what medication may be the best choice for you. I will say that I don't understand why your doctor told you that Prolia has less side effects than the other medications. It's always good to do your own research, so I'm glad you came here. You will find a potentially overwhelming amount of information! Just remember that many people come here to explore side effects and potential problems which are very valid concerns. It's always good to balance that by searching for positive feedback. One thing to explore with your doctor is what sequence of medications they would want to follow and why. Another is whether or not you can afford the medication or would be eligible for financial assistance.
I could go on, but I think this is a good starting point!
Best wishes to you moving forward.

hlp123 | @hlp123 | Aug 11 6:23pm

Thank you so much for your response. I have had an hyperparathyroid adenoma removed in 2001, and the endocrinologist have decided that I should not take tymlos because of this. I seem to be very vulnerable to side effects. I also think I must be immuncomprimised because I got Shingles twice (six months apart) after taking both of the Shingrix vaccines.
Please excuse my spelling. I need to make a decision soon and I am cautious of evenity. I did manage to get through a year of reclast after a year of Prolia, but I am not anxious to take any of these medications. Thank you so much. Lets continue to help each other and support each other. My sacral fractures are not healing and my ribs have fractured without impact on four occasions over the length of 10 years. I am fearful of the "Stroke warning" with evenity. I will probably end up taking Reclast.