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PSE test to inform continued ADT
I had SR to the prostate bed and surrounding lymph nodes last spring which was combined with first 6 months of Eligard followed by 12 months of Orgovyx + Abiraterone. That is supposed to end June 6th. I am going in for bloodwork on April 7th. My Dr has told me I have a 75%-80% chance of cure. I’m wondering if a PSE test could tell more definitively if I’m “cured”. My PSA has been undetectable since at least July of 24. If I got a good result from a PSE test in April, maybe I could stop ADT early?
FYI, I was first diagnosed in August 21. I had GS 8 (4+4) and had persistent PSA post RP.
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The PSE test can tell whether or not there is cancer in your bloodstream. If there isn’t, then you may be cured. I don’t think there’s any way to determine if that it makes it impossible to come back.
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4 ReactionsI agree with @jeffmarc on the PSE test which is 94%+ accurate. You might want to email joe.abdo@oxfordbiodynamics.com. He is a VP of clinical diagnostics at the company that makes it, oxford biodynamics, and he is happy to answer any questions you may have. To quote him, " the EpiSwitch PSE test can be used before, after or during treatment...There are other very informative biomarkers assessing the presence or absence of PCa included in this test."
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3 ReactionsThe PSE test is a real game changer, but my layman’s “gut” tells me to stay on ADT until June.
You absolutely know there are aggressive PCa cells which escaped from your prostate - and you don’t know where they are (were), where they traveled or how degraded they are.
If your doctor gave you 80% chance for cure (as did mine with a Gleason 4+3), those odds are gonna drop if you stop the ADT prematurely.
Is 3 more months on ADT really worth the gamble of it recurring? And if it does, at least you’ll know it wasn’t from any shortcuts you took, you know?
I am the cautious type and even though the PSE test has been heavily touted as 94% accurate, do they REALLY know its efficacy in every clinical situation? For me, the answer is NO but that’s just my opinion and you have to do whatever you feel is the best way forward. Best,
Phil
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