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Posted by smoore4 @smoore4, 3 days ago

Taking a lead from @dpfbanks , I think it is useful to see the core details in a person's profile. I've added the following to mine. A lot easier to do it once instead of explaining multiple times or responding to follow-up questions. My $0.02.

10/2024 - PSA 5.07 - 60 y.o., 4/2025 - RARP (Mayo JAX), Geason 4+3=7. SVI, ECE, Cribiform, Negative margins. 2 out of 12 lymph nodes positive for PCa.
5/2005 - PSA < .1, 7/2025 - PSA .37
7/2025 - PSMA PET - 2 pelvic lymph nodes pos for PCa
7/2025 - Orgovyx and Erleada (apalutimide), 8/2025 - PSA .08
Oct - Dec 2025 - Salvage radiation

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

retireditguy | @retireditguy | 3 days ago

Was "5/2005 - PSA < .1" supposed to be 5/2025"?

jeff Marchi | @jeffmarc | 3 days ago

You have definitely hit the reoccurrence lottery. All of these things are leading to recurrence, Which I’m sure you already know.

“SVI, ECE, Cribiform, Negative margins. 2 out of 12 lymph nodes positive for PCa.”

While a cure with salvage radiation therapy is possible, the combination of seminal vesicle invasion (SVI), extracapsular extension (ECE), cribriform features, and positive lymph nodes (2/12) significantly lowers the probability of a complete and durable resolution. This set of features indicates a high-risk, advanced prostate cancer with a substantial likelihood of persistent disease outside the treatment area.

You could do this AI search to find out more information

“ How likely is it for salvage radiation to resolve SVI, ECE, Cribiform, Negative margins. 2 out of 12 lymph nodes positive for PCa”

It’s good to hear that the ADT and ARSI Are keeping your PSA down. Hopefully it lasts for years.

It would be interesting to hear what your results of the PSA test are after salvage radiation.

There are also a number of treatments in the future if your cancer starts to come back. Hopefully, they come up with something that can wipe out the cancer for all of us. I know for me things are quite uncertain what will happen in the future. I’m going to need those new treatments that are not available yet.

Not sure you saw this, but this seems to be a promising drug, some day. PROTAC ARV-766 Even though it only discusses mCRPC it goes after cancer everywhere in the body, so it should be usable by any prostate cancer patient, if it actually works. Maybe this can solve our problems, some day.

smoore4 | @smoore4 | 3 days ago

In reply to @retireditguy "Was "5/2005 - PSA < .1" supposed to be 5/2025"?" + (show)

yes, thanks for pointing that out!

5/2025 - PSA < .1, 7/2025 - PSA .37

smoore4 | @smoore4 | 3 days ago

In reply to @jeffmarc "You have definitely hit the reoccurrence lottery. All of these things are leading to recurrence, Which..." + (show)

Thank you Jeff. I hadn't heard of ARV-766, also known as luxdegalutamide, until now.

It certainly seems promising that drugs like this, and Pluvicto, which seek out and kill prostate cancer cells, is the way forward. The flip side is you need to be pretty far along before you have access to such treatments. I can imagine using such therapies earlier.

Adding decipher .91 to my profile too. Can I hit the other lottery instead? Florida is up to $700 million now.