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Pluvicto treatment results

Posted by beavers @beavers, 1 day ago

I am an active 86 year old and have prostate cancer. I complete chemo in April 2024. My PSA was 88 and came down to 9.5. Now it has gone back up to 44. I think Pluvicto is next. Can anyone tell me their experience with Pluvicto? I haven't decided my next step yet.

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jeffmarc | @jeffmarc | 1 day ago

Some people have some major side effects from Pluvicto, most don’t. I have heard at least 5 people talk about their experience, In some cases they had to have more time between doses because of the side effects.

I saw a webinar where they discussed a person who lit up the Pet scan With metastasis from head to Legs. He had one Pluvicto Treatment and it almost cleared his pet scan, But his side effects were so bad that he could not take any more treatments

Be aware that it works really well for 33% of people OK for 33% of people and not at all for 33% of people.

If you have certain genetic issues, either hereditary or somatic, it can affect how well Pluvicto Works. You can ask for a somatic test before doing Pluvicto To find out if you’ve got Genetic changes Due to the cancer.

If you have BRCA2 or ATM It seems to work better. If you have RB1, PTEN or TP53 They are Pluvicto resistant. I don’t know if these are the only hereditary changes that cause Pluvicto To work much better or more poorly.

REPLY
1 reply
beavers | @beavers | 9 hours ago
In reply to @jeffmarc "Some people have some major side effects from Pluvicto, most don’t. I have heard at least..." + (show)
@jeffmarc

Some people have some major side effects from Pluvicto, most don’t. I have heard at least 5 people talk about their experience, In some cases they had to have more time between doses because of the side effects.

I saw a webinar where they discussed a person who lit up the Pet scan With metastasis from head to Legs. He had one Pluvicto Treatment and it almost cleared his pet scan, But his side effects were so bad that he could not take any more treatments

Be aware that it works really well for 33% of people OK for 33% of people and not at all for 33% of people.

If you have certain genetic issues, either hereditary or somatic, it can affect how well Pluvicto Works. You can ask for a somatic test before doing Pluvicto To find out if you’ve got Genetic changes Due to the cancer.

If you have BRCA2 or ATM It seems to work better. If you have RB1, PTEN or TP53 They are Pluvicto resistant. I don’t know if these are the only hereditary changes that cause Pluvicto To work much better or more poorly.

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Thanks for the info.
This is the first I have heard about Genetic issues.

REPLY
proftom2 | @proftom2 | 6 hours ago

I start Pluvicto January 20th. Scheduled for six treatments 5-6 weeks apart. Should be interesting. I am classic 5 year aPC journey guy, terrible first year, followed by 2+ years of declining PSA (Hormone Therapy Responding) and now 1+ years slowly rising PSA. Next stop Pluvicto, after that we'll see.

REPLY
1 reply
beavers | @beavers | 4 hours ago
In reply to @proftom2 "I start Pluvicto January 20th. Scheduled for six treatments 5-6 weeks apart. Should be interesting. I..." + (show)
@proftom2

I start Pluvicto January 20th. Scheduled for six treatments 5-6 weeks apart. Should be interesting. I am classic 5 year aPC journey guy, terrible first year, followed by 2+ years of declining PSA (Hormone Therapy Responding) and now 1+ years slowly rising PSA. Next stop Pluvicto, after that we'll see.

Jump to this post

Looks like we are in the same boat.
I started with hormone therapy in 2012, then seed implants in 2014 while continuing the lupron therapy. My PSA started rising the fall of 2023. I started chemo then and finished 9 treatments of the chemo April 2024.
I had a PET scam last week and I am scheduled to see
my doctor this coming week.

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