Nitro-glyercin cream

I haven't seen a nitroglycerin topical mentioned in any other discussion but hopefully someone may have some experience and can share it here. @jeffrapp started another discussion that you might find helpful:
-- Topical creams and lotions for Small Fiber Neuropathy: https://connect.mayoclinic.org/discussion/topical-creams-and-lotions-for-small-fiber-neuropathy/.

I did see an older study from 2015 that mentions the topical.
-- The effect of transdermal nitroglycerin on pain control in diabetic patients with peripheral neuropathy:
https://pmc.ncbi.nlm.nih.gov/articles/PMC4665823/
I only have numbness so suspect that it won't help for that. Do you have pain with the neuropathy?

I was given it for skin healing. It gave me an instant headache so I couldn’t tolerate it. Thank you for posting this. It is new to me.

I have PN since 2018 and I started with Lidocaine/Prilocaine but after some time I actually found Aspercreme with Lidocaine and it is working much better for me on my feet and calf muscles. I did see a posting on on Facebook today stating Protandim NRF-2 The person who posted it said her husband has neuropathy and he found alot of relief with it. I haven't been able to research it myself yet. They stated that lots of science and studies behind it for cellular health. I will be doing my own research about it.

According to Wikipedia, Protandim is a herbal dietary supplement marketed with unsupported claims that it can treat a number of medical conditions. The product is a patented[1] mix of five herbal ingredients and sold by LifeVantage Corporation (formerly LifeLine Therapeutics, Lifeline Nutraceuticals, and Yaak River Resources, Inc), a Utah-based multi-level marketing company.[2] The manufacturers of Protandim make no claims that it can prevent or cure any medical conditions.[3] In 2017, LifeVantage was issued a warning letter by the U.S. Food and Drug Administration (FDA) regarding illegal advertising claims on the company's websites suggesting that Protandim can help to cure various ailments, including cancer and diabetes.[4][5][6]
So this is just another SCAM as is commonly found on FakeBook. Why do people keep looking at that horrible website? Wake UP!

I highly encourage you to look into the research on Protandim! Also be sure to look up "neuropathy and oxidative stress" There are many benefits of lowering your oxidative stress with Protandim!

Hi!
Just an FYI Wikipedia is NOT a trusted research site or valued medical reference.
However, if you go to the site: PubMed -which is operated by the NIH and the National Library of Medicine and considered "a vital resource for researchers and medical professionals to find high-quality, rigorously reviewed scientific information"... type in Protandim Nrf2. There are numerous impressive 3rd party research papers-including one that was a 12 yr study together with the NIA- the National Institute on Aging.

It is true the manufacturers of Protandim make no claims that it can prevent or cure any medical conditions. And there is nothing said specific to any disease or condition. But they can state it lowers oxidative stress by up to 40% in 30 days.
Now go look up "what is the benefit of lowering oxidative stress"
Hopeful to help others lower their oxidative stress!

There is a nitroglycerin transdermal patch used to treat neuropathic pain but not a cream. There used to be a cream years ago that we used in the emergency room to treat cardiac chest pain and I don’t believe it’s available for the general public.

This is an interesting idea. PN is associated with vascular and nerve damage. Which causes which? To me it's a chicken and egg problem.
I read the article (thanks John). It's a very small study, but ir does appear to show statistically valid moderate improvement. I searched PubMed for more studies, but I can't find much.
NTG patches often are associated with adverse symptoms, particularly headache and dizziness. They are mostly used for patients with angina.
I'm going to contact my neurologist to see what she thinks. I may try this as an experiment on myself. I'll post with results.