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New study - 100% success, zero recurrence, and low toxicity
I know it is not a human trial, but 100% success, zero recurrence, and low toxicity are just not findings that happen everyday, in any cancer treatment let alone pancreatic. This is huge news imho.
https://www.livescience.com/health/cancer/new-triple-drug-treatment-stops-pancreatic-cancer-in-its-tracks-a-mouse-study-finds
Here is a summary of the article and the study it describes:
Overview A groundbreaking study led by researchers at the Spanish National Cancer Research Centre (CNIO) has found a new "triple-drug" combination that completely eliminated pancreatic cancer tumors in mice. The treatment not only stopped tumor growth but caused them to disappear entirely without returning, a feat rarely achieved in pancreatic cancer research.
The "Triple-Drug" Strategy Pancreatic cancer is notoriously difficult to treat because it quickly develops resistance to single drugs. To overcome this, the researchers simultaneously attacked three different critical "pathways" that the cancer uses to survive and grow. The combination included:
Daraxonrasib (RMC-6236): An inhibitor that targets KRAS, a gene mutation found in over 90% of pancreatic cancers.
Afatinib: A drug already approved for lung cancer that blocks EGFR, a receptor that sends growth signals to the cell.
SD36: A new experimental drug that degrades STAT3, a protein that helps cancer cells survive under stress.
Key Findings
100% Success Rate in Mice: The treatment eliminated tumors in all mouse models tested, including those with aggressive human pancreatic tumors grafted onto them.
Zero Recurrence: The tumors did not grow back for over 200 days after the treatment ended (a significant duration in the lifespan of a mouse).
Low Toxicity: Despite using three potent drugs, the treatment appeared to be safe and well-tolerated by the mice, with no significant side effects.
Why This Matters Current treatments for pancreatic cancer (like chemotherapy) often fail because the cancer finds "escape routes" to survive. By blocking the main driver (KRAS) along with its upstream (EGFR) and parallel (STAT3) backup routes, this therapy effectively corners the cancer cells, leaving them no way to survive or mutate.
Next Steps While the results are promising, the researchers caution that human biology is more complex than that of mice. The team is now looking toward the lengthy process of adapting this regimen for human clinical trials to see if it can offer the same life-saving potential for patients.
God, please be the one!
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Does anyone know the common name for this drug noted above, as being commonly used for lung cancer? Afatanib=?
Since RM6236 is about to be publicly available, and this one for lung cancer already is; sure wish SD36 was further along.
Many know that the RM6236 drug is currently being tested in tandem with Gemzar, folfurinox, and Naliri in separate human trials that are already at phase 2 or phase 3. Wish these are drugs could be dropped in as well!
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1 ReactionI remember a scientific seminar I went to 30 years ago where the speaker's conclusion was "if you have cancer, and you're a mouse, we can help."
This study does sound promising and hopefully will translate to humans. But there's a long history of drugs working much better in mouse models than they do in people.
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4 Reactions@gamaryanne
Brand name is Gilotrif according to AI
@val64
That is funny!
Mice not born with pancreatic cancer mutations so clinical trials don't always translate the same for humans.
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2 ReactionsI know everyone on this site would be willing to try it!!! I know we would.....in a heartbeat!!
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1 Reaction@val64 Val64 your comment comes across as negative. I am a pragmatist, so I understand why you made that comment however when you have cancer as I do, I believe it's best to be positive but that's me.
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2 ReactionsI agree @doonman .
Don't knock hope.
Mouse studies are the first of a number of important steps. A lot has changed in 30 years, particularly pancreatic ca. There is significant progress with biomarkers (e.g. lab tests for early detection), vaccines, and treatment. It's time!
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1 Reaction@smoore4 @doonman
I believe @val64 was adding a bit of levity to the subject. Nothing more. Nothing less. As someone that has been battling pancreatic cancer for 3.5 years, maintaining a sense of humor has helped me survive. Let's just move on please. Thank you.
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9 Reactions@tomrennie
Yes, agreed. A bit of levity based on the fact that hundreds of studies are offered each year that have been successful on mice and very few offer long lasting benefits for humans; you have to find humor in that. Not one saying not to try as you never know which one will work. I tried histotripsy even when the oncologist I respect the most said he didn't believe in it and voila it worked on the lesions in my liver; I wonder if they tried it in on mice first - ha ha!
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5 Reactions@tomrennie
I'm almost at 3.5 years also, but now battling how I can stop this peritoneal metastasis. If I may ask, are you "cancer free" now? I feel very good with the exception of some internal neuropathy. My dad only made it to 7 months (26 years ago), so I feel blessed!
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