Neuropathy + Proton-pump Inhibitor use?? Anyone had this experience?

Posted by piross1528 @piross1528, Sep 11, 2021

Hello there,

I am experiencing symptoms of SFN and am wondering if anyone has ever made this connection, had this experience, or heard of such a thing. I am looking for the cause of my neuropathy and the only med I currently take is Prilosec and have been daily for about 2 years. However, my serum B12 levels are high. I have recently discontinued the PPI and am really hoping the symptoms resolve as this has a been a difficult time for me emotionally and physically. Has anyone here ever had a neuropathy they believed to be linked to PPI use? Thank you! Steve P

Interested in more discussions like this? Go to the Neuropathy group.

@piross1528 I don't know if you've come across this paper, but thought I'd share in case it helps you as you continue to explore the connection.

– Proton-pump inhibitor use is associated with a broad spectrum of neurological adverse events including impaired hearing, vision, and memory:,compared%20to%208%2C309%20H2RA%20patients.
Have you shared your thoughts with your doctor?


Hello Amanda, thank you for your response. I have already read this paper and am not sure what to make of it! It seems like there is definitely a chance the two are connected but I have never spoke with anyone else who has made the connection. The PPI is the only medication I have been taking before the neuropathy flared up. I had some very similar symptoms in 2018–I stopped taking the PPI and they resolved. There is no way to really know for sure if they are related—but at this point I am really desperate to find a cause to the pain and nerve damage. Anyhow, thank you for your response Amanda!

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