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My Gleason score is 7 - 3+4. How long can I live without treatment?
My Gleason score is 7 - 3+4,. How long can I live without treatment? Since I decided not to get any treatment, because of horrible side effects, I was wondering, if someone who experienced the same condition, will share his experience with me.
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HugInterested in more discussions like this? Go to the Prostate Cancer Support Group.
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I assume your Gleason Score 15 is a typo . No matter , have a 2nd or 3rd opinion of your biopsy results before making any knee jerk decisions you may regret . Read Dr. Patrick Walsh's Book "
Guide to Surviving Prostate Cancer . YOU ARE NOT GOING TO DIE TOMORROW , YOU MAY HAVE HAD THE CANCER 10 OR 12 YEARS . Do you feel any different today than you did before your diagnosis . I agree , stay away from hormone treatment if at all possible . If you must go forward with treatment investigate , what is becoming the go - to treatment for low risk and favourable intermediate risk prostate cancer . SBRT 5 Treatments . Typically Mon-Wed-Fri AND Mon Wed the following week . I am on AS for over a year . I " MAY " consider MONOTHERAPY SBRT . Yes MONO -- no ADT etc .
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Hug
1 ReactionI too have PC, first suspected last March, PSA 5.2, then MRI showed something, subsequently confirmed by biopsy as Gleason 3+4, PSMA showed contained within gland and no spread. After a bunch of reading I couldn't decide on a treatment, but I swore I would not do ADT. I told myself I would have surgery before that. However, after having the Artera test (showed I have a biomarker that indicates a significant risk reduction with short term ADT) and speaking with a couple radiation oncologists and medical oncologists at different highly regarded cancer centers, well - I start Orgovyx tomorrow, with RT starting in 2 months. I exercise and eat well already, so hopefully it won't be that bad.
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Hug
3 ReactionsExcellent post! This is why Decipher and other tests are so important - not every Gleason 3+4 or 4+3 is the same…good find.
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Hug
1 ReactionThere are lots of studies/trials out there that address this question. If you want a valid answer you should be looking there in large populations and scientific analysis rather than asking for one-off, anecdotal responses here. JMO.
Here is a link to one such study:
https://pubmed.ncbi.nlm.nih.gov/31909690/
and here is the abstract:
Abstract
Purpose: To study the risk of metastatic prostate cancer development in men with Grade Group 2
disease being managed with active surveillance (AS) at Memorial Sloan Kettering Cancer Center.
Materials and Methods: 219 men with Grade Group 2 prostate cancer were managed with AS
between 2000–2017. Biopsy was performed every 2–3 years or upon changes in magnetic
resonance imaging, prostate-specific antigen (PSA) level, or digital rectal examination. The
primary outcome was development of distant metastasis. The Kaplan-Meier method was used to
estimate treatment-free survival.
Results: The median age at diagnosis was 67 years (IQR 61, 72), the median PSA was 5 ng/mL
(IQR 4, 7), and most patients (69%) had non-palpable disease. During follow-up, 64 men received
treatment: 36/64 (56%) radical prostatectomy; 20/64 (31%) radiotherapy; 3/64 (5%) hormone
therapy; and 5/64 (8%) focal therapy. Of the 36 patients who underwent radical prostatectomy,
32/36 (89%) had Grade Group 2 disease on pathology and 4/36 (11%) had Grade Group 3.
Treatment-free survival was 61% (95% CI 52%–70%) at 5 years and 49% (95% CI 37%–60%) at
10 years. Three men experienced biochemical recurrence, no men developed distant metastasis,
and no men died of prostate cancer during the follow-up. The median follow-up was 3.1 years
(IQR 1.9, 4.9).
The key takeaway is: "Treatment-free survival was 61% (95% CI 52%–70%) at 5 years and 49% (95% CI 37%–60%) at 10 years."
Caution: This overall result is with all types of Grade Group 2 subgroups rolled up into one. The details of your pathology and imaging might mean you could expect shorter or longer times until you haveto seek treatment.
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Hug
3 ReactionsWell, I exercise and eat right, so I have those two things going for me.
What about Orgovyx? No shots, side effects minimal if you exercise and eat right. ADT (hormones) could be the game changer for you.
cianci, I'm 78 too! Chose surgery, completed in May 2024. Subsequent PSA at 3 months= 0.009, and six months= 0.006. Not saying surgery is best for everyone but no regrets here. My detailed story in link below in reply to another post. It is a challenging journey! Mayoforums has helped me greatly.
Best
https://connect.mayoclinic.org/discussion/76-too-old-for-surgery/?pg=2#comment-1075893
Why won't you combine ADT with radiation?
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Hug
2 ReactionsYou are correct when they say you live this long or that long if, the fact remains that the way you die is horrible as it would be in any cancer I suppose. I did watch my father get eaten away by this disease and it wasn't pretty.
I have a question to anyone out there: I have prostate cancer discovered in April with a biopsy precipitated by my Gleason score of 15 and one 3 4. I'm ready to go through with the radiation but I'm not hopeful seeing I will not take hormone shots. Does anyone know of Dr Makis and or Dr Howe and their use of Ivermectin?
I'm 55 with a 1.2mm lesion and just got biopsy result with nearly half the cores Gleason 3+4 throughout much of the prostate. Recent PSA was just over then just below 4, with nothing to reference for several years before that. Still waiting to see the doctor, but preparing for the hard sell on removal. Like @cianci I'm curious what your other numbers where like, and how they've progressed over the years.