Met w/Endo after self-directed Tymlos start--shocked he's ok w/HRT
I (62/F) dove in and rather aggressively pursued a PA and coverage for Tymlos after discovering I have OP following a fracture (accident on ice) that led me straight to a Total Hip Replacement a few months back.
I've met my out of pocket max for the year and wanted to get a few "free" pens before year-end, so my PCP wrote the script and urged me to get in with an Endo as soon as possible to manage my journey.
I was super happy with the provider I ended up with. He gave me the green light to call and take him up on starting low-dose bioidentical HRT after I research it (I expected the same "no" I've received from everyone else given my age and being 10 years past menopause). And though he doesn't use bone turnover marker (BTM) bloodwork (except with patients he fears are non-compliant with taking their meds), he said he'd be glad to order the BTM labs if I want them for my file as long as I check that my insurance will cover them.
My PTH, serum calcium, TSH, eGFR, and Vit D were all in range, but my creatinine was really low at .4 (reference range .7 - 1.2 mg/dl).
Possibly related to that, getting ready for my appointment I noticed my pants were loose and jumped on the scale and saw that I've unintentionally lost 4 lbs in the last month since starting Tymlos. I meant to ask him about my low appetite and weight loss on Tymlos, but I forgot (!). (At 62 I don't want to lose beyond my set weight of 134/5 because it just comes off my chest and scarecrow arms anyway and I don't want to lose the bit of muscle I've worked kinda hard to build).
True confessions, I had already been checking out my belly a few times a week, trying to discern if I am getting the 7-months-pregnant Tymlos pouch that so many of you have described... The jury is still out on whether it's truly bloated/ distended, but I can confirm that it's kind of bumpy (looks like a topographical map when I look down at it), so maybe it's on its way to the 3rd trimester look (?).
And @windyshores , he (my doctor) loved your saying that "Tymlos 'eats' Vit D." He said it absolutely does and he approved your personal protocol of adding another 1000 iu a day to offset what the Tymlos is burning through. My Vit D has been right at 50 for years, but yesterday's bloodwork (while still in range) showed it dropped to 40 after only 5 weeks of the med, so I'm eager to get started with that extra 1000 iu right away :-).
I don't know if I'll have time to do a deep-dive on HRT for over-60's before Christmas, but I'm exhilarated and heartened that he didn't say "no." All you HRT vets, what does an rx for low dose estrogen, progesterone and maybe a little testosterone include and look like these days? Most of what I read talks about patches being best for the tiny dose I'd be aiming for, but that's about all I know. (If I decide to go for it, I will want to quickly become a black-belt on getting an HRT PA, too, because I definitely don't want to pay full retail for it.)
Peace and warm wishes to all as we enter the thick of the holidays!
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Can you share your beginning Dexa scores? I, like you, have just started Tymlos while also starting Testosterone (waiting to add Estradiol and progesterone). I also added one tablet of fermented cod liver oil to my algaecal D3/K2 for more vit. D. I am 63. I’m on 3 clicks in 1st 3 days. Going up to 4 tomorrow as I will not start at full dose. Look forward to comparing results….
Annie208, Are you planning to add HRT to your ongoing tymlos treatment, or to start HRT after the completion of tymlos? Since you didn't have a baseline btm prior to tymlos, it will be nice to get a serial btms (2-3mo, then 6mo) for tymlos to see how it is working for you. On average p1np responds greatest in early months of tymlos treatment (1-3mo) although individual variation exists. Adding HRT now will obscure btm results.
My HRT consists of a low dose estradiol (E2) patch and an oral gelcap of micronized progesterone (generic for Prometrium). Wi5h insurance i pay $20 for 3mo supply for either meds. One of the cardiologists whom I consultedwith advised me not to take testosterone. Maybe you could ask the inclusion of testosterone when you seek opinions from your obgyn and cardiologist.
Can you share his reasoning about not including testosterone. I ask because I understand that both testosterone and estradiol are helpful for bones. I started on all three about 4 months ago. Thanks
I sought a second opinion from this cardiologist who speciazes in women's cardiovascular care and was recommended by several doctors. She advised me not to use testosterone after reviewing all my labs and tests. I didnt ask further since I was focused with estradiol + progesterone therapy for bone benefits with no testosterone treatment in mind at the time. My background was a mild cad (38 cac score at lad), LDL-c controlled by 5mg crestor and pre-diabetes controlled via a heart healthy diet. I dont have a family history of cvd or metabolic diseases. The cardiologist reset my LDL-c target to less than 55 and HbA1c to equal or less than 5.6 and told me my heart should last into my 90s and that adding estradiol +progesterone therapy wont present a problem. Now my worry is my bones won't last that long 🙁
Thank you. I like to think that the more we share our experiences..the
easier it is to make these tough decisions...