Do people with an ileostomy metabolize medication differently?

Hello yoopergal-Reading your post took me back to my experience with my temporary colostomy. If you care to, you can track my posts during my 'saga' beginning December 21, 2021.
I don't know if ileostomy requirements are different from colostomy and it might be that the solution I found is not recommended. During one of my ER visits, this one for my recent colostomy leaking bloody stool, the ER doctor used Tincture of Benzoin as the 'paste' to seal the appliance. I applied the tincture both to my skin and the disc (I've forgotten what it is called) that adheres to the skin. It was a game-changer for me, as I also had frequent adherence issues. The Tincture is normally used in wound care to ensure that steri-strips will stay on a newly sutured area.
It allowed me usually 5 days before having to change the bag. I was still under the care of a home care nurse at the time and she has since offered that to her patients who are having similar problems. It takes more effort to remove and clean the skin when the appliance needs to be changed but it was so worth it for me! Good luck to you! PS, I was almost 78 years old when I had the colostomy. I thank my lucky stars for this website to allow the additional help we need from time to time from peoples' experiences and suggestions.

I received a “ temporary “ iliostomy in 1989….. that lasted about a month before the doctor and I decided to never hook me back up to my rectum. It’s now been 34 years and though I’ve had many trials I think everyone should be born with one!
The past three years I’ve had many procedures at Mayo and am now back in remission.
I am a 71 yr. Old female. Had two children while I had Crohn’s disease and before my surgery.
I have tried Holister and Convetec… I’ve lost 100 pounds in the last two years so it’s hard to get my appliance to adhere to my skin. ( my skin is old, saggy and a railroad track of scars!)Sometimes I would change 12 times in one day…. Yesterday it was 3 times … and today so far it’s good. Seeing an ostomy nurse can help try different applications that could work for you.
I’m glad that I found this site… as old as I am and as long as I’ve had the ostomy - I am still learning

Some medication, such as liquid Cymbalta may not be available in the US. The doctor recommended that I open the capsule and sprinkle the contents on something like apple sauce.

Liquid, needle or pill if it still has the same side effects it's something I don't want.

G13, you may also wish to join the discussions about ankylosing spondylitis in the Autoimmune Diseases group https://connect.mayoclinic.org/group/autoimmune-diseases/

Might the medications for AS be available in oral liquid form or as an injection as suggested by @kenc and @steve1k ?

I've been an ileostomy'er for 22 years, now 71 years old, and have just been diagnosed with ankylosing spondylitis by a rheumatologist. Been suffering from Back, Hip, Knee, Kidney stone, Muscle ache, nausea pain for 14 years, and now Neck and Shoulder Pain. I also have been curious how fast oral medicines pass through the body of a person without a colon ( ileostomy patent )? I fear the new med that is being proscribed for me, after reading the warning of the side effects of HUMIRA.

I am interested to know about the metabolism of meds with an ileostomy? --- Should meds be regulated differently? I am learning to cope with an ileostomy and am happy to discover this Mayo clinic support group!

Yes, I've seen medication come out whole. I take medication with meals, if I have to.

IM works best if you are trained to give injections, this way the medication does not go through the intestines. If you have Crohn's with an ileostomy, the large intestine absorbs anything ingested. This is why medication dosages may change depending on if the disease is active or in remission. I have taken pills for Crohn's and they were not absorbed. I could tell this as I saw the whole medication in my ileostomy output. Everyone is different. I have lived with Crohn's for 50 years.

Yes, they do