Lupron Treatment Duration: How long were you on it?

Posted by frankstags @frankstags, Jul 7, 2020

I have been diagnosed with Grade 3 prostate cancer with a 4 + 3 Gleason score of 7. This after having 2 PSA scores last year between 4 and 7. The cancer has not spread to the bones. I have received two Lupron injections 3 months apart and will complete 28 radiation treatments in the next couple of days. No surgery. I have tolerated the Lupron shots well with few but manageable side effects. I have an appointment to receive a third Lupron shot next month. My first PSA test after completing radiation won't be scheduled for 3 months. From researching Lupron, it appears that this is used for advanced stages of prostate cancer. From what I was led to believe, I was not advanced. My question: How long and how many Lupron shots might I need to go through? I will have this discussion with my urologist hopefully before proceeding with the next shot. Thanks for any information provided by the group.

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Hello,
I was diagnosed at age 66 with G8 4+4 PC, the treatment that I chose was radiation and that was 45 treatments over 9 weeks and then 12 months of Lupron. Ice been off Lupron for 1 year now but I have no Libido, no stirring, no desire to even try, if I try to master bate it's like beating a dead horse, I have a penile implant but there just aren't any feelings, my breast's became moobs and I really would enjoy intimacy with my wife again but there just isn't any fuel in the tank. I have no idea if I'll ever feel intimacy again and now I'm only 68 years old, to young to just give up.
Thanks for reading, any comments are welcomed

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I too was 4+3 G7. 66 year old, PSA was 10 after a failed Hi-Fu. I was informed by my radiologist that based on my numbers, ADT was recommended to compliment the radiation effectiveness. It seems there is a higher success rate when combined. Not wanting to take any more chances, I went with the prescribed 4 mth ADT program and 28 Rads. Testosterone went to 2.5. After 9 mths, PSA still undetectable 0.02, However, most recent PSA showed slight uptick to 0.08, (T level reached 300), hopefully nothing to worry about.....Best to all

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@rkj2019

What are /were your side-effects from Lupron and also Nubeqa? Do you have libido after all hormonal therapy? Leg weakness, joint pain, brain fog, gynecomastia?

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@rkj2019, you may be interested in these related discussions:
- Gynecomastia (male breast enlargement) bc of ADT-prevention/experience https://connect.mayoclinic.org/discussion/gynecomastia-male-breast-enlargement-due-to-adt-can-it-be-prevented-1/

- Gynecomastia while taking hormone therapy for prostate cancer https://connect.mayoclinic.org/discussion/gynecomastia-while-taking-hormone-therapy-for-prostate-cancer/

- Can we talk about boobs please? Man Boobs. ADT induced gynecomastia. https://connect.mayoclinic.org/discussion/can-we-talk-about-boobs-please-man-boobs-adt-induced-gynecomastia/

You can use keywords in the group search to find other related discussions, like https://connect.mayoclinic.org/group/prostate-cancer/?search=Leg+weakness#discussion-listview

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I was on luprone and Erleada for a year and it was tolerable. Some brain fog, flashes, sleep disorder , loss of sex drive but it was medicine that has helped to keep me undetectable for 3 years. I am G 9, CR, locally advanced.

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@doors4ever

Late to the conversation. Just wondering why your not seeing an oncologist at a cancer center? I was diagnosed with agressive metastatic stage 4b pc. PSA 40. Gleason scores all 4+5 or 5+4, Pirads 5. Spread to pelvic bones and lymph nodes. 6 docataxel chemo treatments, 6 radiation treatments, 2 years Lupron and Nubeqa and PSA is holding at .02. PET scan shows no cancer. Even bone cancer is gone. I went to MN Oncology. Just can't say enough about the great treatment I got there.

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What are /were your side-effects from Lupron and also Nubeqa? Do you have libido after all hormonal therapy? Leg weakness, joint pain, brain fog, gynecomastia?

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@doors4ever

Late to the conversation. Just wondering why your not seeing an oncologist at a cancer center? I was diagnosed with agressive metastatic stage 4b pc. PSA 40. Gleason scores all 4+5 or 5+4, Pirads 5. Spread to pelvic bones and lymph nodes. 6 docataxel chemo treatments, 6 radiation treatments, 2 years Lupron and Nubeqa and PSA is holding at .02. PET scan shows no cancer. Even bone cancer is gone. I went to MN Oncology. Just can't say enough about the great treatment I got there.

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I was on Lupron several years. The last time my cancer recurred I went to UCLA for a PSMA PET scan. Four metastases were found. I underwent SBRT for them, took Nubeqa for 24 months, then stopped all treatment. My PSA has been < 0.008 since.

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@scullrower

My understanding is that the cancer becomes active again while getting Lupron because it has developed ways of producing its own testosterone and is less dependent on the testosterone made by the body. Lupron, however, still slows cancer growth to some degree. This is probably an oversimplification but, as a layman, it’s the best I have.

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Late to the conversation. Just wondering why your not seeing an oncologist at a cancer center? I was diagnosed with agressive metastatic stage 4b pc. PSA 40. Gleason scores all 4+5 or 5+4, Pirads 5. Spread to pelvic bones and lymph nodes. 6 docataxel chemo treatments, 6 radiation treatments, 2 years Lupron and Nubeqa and PSA is holding at .02. PET scan shows no cancer. Even bone cancer is gone. I went to MN Oncology. Just can't say enough about the great treatment I got there.

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@colleenyoung

@zr2, that's a tough decision when specialists offer differing opinions on the length of ADT. Did you stop after 9 months or will you continue? Did you bring the urologist's evaluation to the oncologist to discuss?

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I was diagnosed at 71 psa was 7.3 I had minor EPE and ended up having radiation for 28 days and was on Lupron for 2 yrs with injection every 3 months .
I also was treated with Casadex for 2 years.
I am 74 now and have been off of Lupron and Casadex for 16months.
My psa is undetectable and my T is starting to come back!

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@zr2

I’m 69 , was diagnosed with prostate cancer after biopsy PSA of 10 and total 7 for Gleason. My cancer was aggressive didn’t metastasize and was only contained in gland. I opted for 25 radiation treatments resulting in undetectable cancer and PSA. I have received 3 lupron 3 month shots. My oncologist wants me to continue for total of 18 months minimum. After consulting with my urologist, she recommended 6 months was sufficient based on my history and diagnosis. I’m leaning towards stopping now at which it will be 9 total months. I can respect my oncologist decision to look farther ahead but my urologist made strong support for discontinuing. What are your thoughts?

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@zr2, that's a tough decision when specialists offer differing opinions on the length of ADT. Did you stop after 9 months or will you continue? Did you bring the urologist's evaluation to the oncologist to discuss?

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Age 74, Gleason 7 (4+3) diagnosed 2/15/22. Lupron 3/27/22, IMRT 39 ZAPS,
9/1/22 Zytiga + Prednisone.
As of 8/15/24 (Date of freedom from drugs and treatment)
24 mos of zytiga
30 mos of lupron
39 zaps of IMRT
BOY AM I TIRED! Now age 77
Good luck to all you guys.

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