Lupron: Anyone have muscle weakness and severe leg pain?

@bonjas

No warnings from doctors on these extremely painful and debilitating side effects. The manufacturers should be called to task. Household items come with safety precautions so why do these painful meds come with no precautions or suggestions. This should be illegal!

@edmond1971
I'm on every 3 months shots of Eligard for 2 years regimens my last shot is coming up in January and can't, Eligard is not a joke brain fog, dizziness when standing, lack of coordination, forgetting a lot and losing muscle mass depending on your age going to the gym helps a lot not easy just show up.

@maga

My legs and arm muscles began to painfully burn about 6 months after stopping Lupron. I also had severe headaches, brain fog, sweats, and enlargement of my heart. The muscle and head pains began to subside after 6 more months. My head hurt so bad that it was painful to even touch my skull. I am 83 years old and was stage 3 diagnosed in March 2025.

I also have PC and have been on Lupron injections every 3 months for 15 months and have stiff legs and hips for about 3 months. I was doing OK until about almost 3 months ago. I then started feeling tired and started losing weight.

@gaws a quality electric blanket and ski socks have greatly helped me manage the leg cramps and pain.

@gaws

After 44 radiation treatments and 4 months of Lupron I had to stop the Lupron because of severe 24/7 sweating, headaches, leg pain and cramps, and joint pain in general. I stopped because i thought that the Lupron was going to kill me. After 5 months the side efects have dropped in severity by about 50%. I have < 0.1 PSA and < 7.9 testosterone on tets at 1 and 3 months after exiting Lupron. I am 83 and exercise hard about 4 days per week. Your husband's experience is normal for some people.

@gaws I just started reading this forum and asking questions while watching a friend go through it, and have found many existing discussions very helpful, too. Yes, it seems the side effects are very common.

I just wanted to add that the "surprise" from doctors who never mention the side effects of a treatment, is even more common across like 90% of doctors and 90% of drugs for 90% of conditions! The Internet has made a real change in medicine for patients to help share real information from actual patients. Just maybe medical practice is becoming a little more open about what they already know well. For many years they were specifically taught to not scare the poor patients who might then avoid or decline treatment or imagine side effects that they aren't really suffering! While these are real issues when it comes down to it I vote for honesty.

I am on this site to see if I can find help for my husband. I really appreciate the comments about the antihistamine and the strength resistance training. Also the suggestion to drink liquid protein after exercise. My husband was a runner and a mail man for many years. Since he has been on lupron, any exercise causes his legs to ache and often he has shooting pains. His doctors have never suggested this as a side effect. In fact , when we've mentioned it , they've seen surprised. So all these comments are very helpful. Especially knowing he is not alone in this pain.

I get cramps in my calf’s

I have been getting cramps in my thighs almost every day night 🤷‍♂️