Lupron: Anyone have muscle weakness and severe leg pain?

Thank you all for your posts. I have seen numerous comments about fatigue and loss of strength. I thought I’d give an update too as an encouragement to others.

Eight weeks ago I started trying to rebuild some strength and combat this fatigue. It’s been slow but I have seen progress.

I started walking on an incline treadmill at 12% 1-2 x per week at least 2-3 days apart. Although this sounds difficult, I started at 1 mile per hour and only for 2-3 minutes. At that rate, it’s very easy. I wanted it easy so I wouldn’t get overwhelmed.

Each time I increased the length of time slightly but didn’t really push the workout. I also began to slowly bump up the speed only by .1 mph, again not really pushing myself.

I found that I was comfortable sometimes adding 5-10 minutes. It’s been 8 weeks and I hit 60 minutes for the fist time. I still go pretty slow…about 1.5 mph.

I also began going for distance walks at a local metropark. These are pretty flat. At first, I struggled even with a quarter mile. I repeated my walk once each weekend, trying to go a little further each time. I found I had to rest frequently. I still walk much slower than I used to, but in 8 weeks I am up to 3 miles.

I still get fatigued easily. I finished the chemo 1 year ago and the radiation 9 months ago. I’m not setting any records and just about everyone passes me on the trail.

It just feels good mentally and physically to be going in a positive direction for a change.

I should note that I have currently been on quarterly Lupron injections for 18 months and my doc wants me on these for another couple years. I am also 294 pounds and 60 years old.

My prayers for you all are for your complete healing. Thank you all for your support and relaying your experiences. Blessings to you all as you keep up the fight.

I’m suffering the same way. Legs so weak I can barely do stairs. Is it the low testosterone or side effects of Lupron?

Good luck, God bless, I'm 69 here. Have a good weekend.

I stopped Lupron in August of last year (2022).

My testosterone still has not returned to within range.

I have not dared walk to the store for the last year, for my muscle mass is too weak, and I am afraid of stepping up on curbs and stepping down from them.

I realize that age makes a big difference in the speed of recovery. . I am 86.

So, kam23, your latest post says that the Lupron wasn't the cause of the leg pain, right?
FYI for the thread: I've been on 3-month leuprolide/Lupron for a year, I think, and recently added abiraterone/prednisone. No pain, but I notice I can't climb as many stairs as I used to, or as easily the ones I still can -- perhaps unrelated to the ADT+, though.

I can surely understand. My daily 3 mile walk, which is fairly elevated is
much more difficult now than before hormone treatment. Hips down to
the feet. Ibuprofen helps slightly. Little feedback from the urologist, and
oncologist!

Lupron severely adversely effects your muscles. I have difficulty getting out of my chair and unstable in my walking. Gleason 9, CR, aggressive, locally advanced. I am told that it helps to keep me alive so I willingly accept the side effects. I was taken off all meds 10 months ago but I still feel side effects from Lupron and Erleada

Ditto for me. Lupron isn't easy

I identify with your leg pain. Gleason 9. Metastatic. I’ve done chemo and radiation, now on Lupron and Nubeqa. So weak I can hardly climb steps. Physical therapy helps. Several short walks or exercise bike rides per day seems to help.

Hand pain. I was on Lupron and Erleada for 13 months and I have been off all meds now for 10 months. About a month ago I got pain in my right hand and fingers and I cannot now make a fist and the palm and back of that hand and fingers ache and burn and hurt. The pain is now starting in my left hand. Has anyone else had this sort of problem and if so can you give me a recommendation. Tylinol 8 hr and arthritis cream help, but I am looking for other treatment. Thanks