Lupron: Anyone have muscle weakness and severe leg pain?

I was a pretty good marathon with decent speed running 30-40 miles a week. Received a Lupron injection 6 months ago and completed Proton radiation 4 months ago. PSA is was tested 2 days ago and is undetectable. For past 2 months I have been dealing with leg pain during runs staring in mile 2 or so. Legs feel like mile 30 of a marathon with so much discomfort I only managed 4 slow painful miles today. Doctors don’t give me a definitive answer.

I know I am lucky to be out there but can anyone tell me of similar experience and if you ever got past the leg pain. This only happens when I run.

Of course I have other side effects like hot flashes.

Thank you
Al runner

I would not stop the Anastrozole which lowers estrogen and is given to woman at risk for breast cancer. I take Anastrozole, Amour Thyroid and Clomid for low testosterone. The Lupron lowers your testorone to near zero and this is what is responsible for the way you feel. Have you had radiation for the prostate cancer or is it so mild they chose to treat it with Lupron.
You must at least have good insurance because the Lupron shots are like $5k
Five years on Lupron is crazy.

65 yo male, Brac 1 positive w/ breast cancer & mild prostate cancer. Have endured monthly Lupron shots for 6 mo. while taking anastrozole daily. Also developed L4-L5 spinal stenois and osteoarthritis in both hips and knees. 5cm breast tumor shrinking but with every Lupron shot groin & thigh pain getting worse and worse. Very sexually active before Lupron and know not in 5 months. On a walker 95% percent of time and cane the remainder. I'm still working full time and quality of life is dismal. No pain or discomfort from cancer but leg and hip pain very debilitating. Considering going against Dr. and stopping Lupron & anastrozole after tumor removal scheduled for February 2025. Dr. had suggested Lupron for another 5-10 years after surgery. No way.

Welcome, @mkhaz123. A few members have taken Nubeqa, although I'm not sure for how long. Check out these related discussions:

Search results "nubeqa" https://connect.mayoclinic.org/group/prostate-cancer/?search=Nubeqa+&index=discussions

I was on lupron and Erleada for 13 months and that started 30 months ago. I am 76, Gleason 9, CR, advanced PC and I had RP in the 7th month. The meds certainly slowed me down , slept poorly, lost muscle, gained belly fat, but this was all manageable. My T went down to 9. I have been off of meds for 15 months. My T is 100, my PSA is .01. I am on a plant based diet. I am committed to living a good life with my friends and family as long as possible. I am in favor of denying my cancer of as much of the testosterone food as possible.

Testosterone gets a bad rap with prostate cancer treatment. It does not cause cancer but will provide fuel that causes the cancer to grow faster. I have heard the phrase that Testosterone is like rocket fuel for Prostate Cancer I think a better analogy would be Lighter Fuel.
Have you had a Testosterone test?
Six months after radiation and Lupron my Testosterone was about 530 and I felt like crap all the time. After my first dose of T all the problems I was experiencing went away within a couple of days. My Urologist was strongly opposed to the treatment and denied that there was any downside to Lupron Treatment. I got a new Urologist who is agreeable with the treatment and not concerned.
If you take Testosterone your PSA will go up it is part of the biochemical process. I went from a PSA of .1 to .54 but it stabilized there.
Testosterone Is what makes you a man and helps with drive, healthy bones and Muscle development and there are negative consequences to lowering it.
I am 67 and healthier than I have been in a long time I would rather live another ten years healthy and active then 15 in the nursing home.
There are a number of good YouTube videos from Urology seminars that address that address TRT after Prostate cancer.

Leuprolide works by reducing the amount of testosterone that the body makes. This helps slow or stop the growth of cancer cells.
So I am curious to understand
How to start testosterone therapy and kept your PSA normal can you elaborate on this and this was your dr recommendations?
Thanks

I have the same symptoms ,69 yrs
My PSA was 65 in 2021 I had metastasis stage 4 I had radiation to my hip 2021 and start my Lupron injection every 6 mths, muscle cramps once a while ,hot flashes,tingling hands and feet too
6 months ago my PSA start creeping up from 0.1 to 1.2 my oncology had me on second generation called Nubeqa iam in remission since but I am thinking to stop the Nubeqa and watch my PSA for 3 mths .
Anyone taking the same medicine for long time?
Thanks

I believe that any exercise that you can manage is helpful.
At 73, I have always been a gentle walker.
Regular walk about 45 mins thru the neighborhood.
After RP, I was fine.
During Salvage radiation and 4 mos of ADT therapy, I felt like I was walking uphill all the way, and into the wind, all directions. Became 50+ minute walk, and a serious effort.
After about 3 mos off tx, my energy started to return. And I now feel pretty well and back to 45 mins.
I also lifted 15 & 25 lb dumbells a couple of times per week (1 set each, 20 - 30 reps). Lifting also impacted during therapy and after; and now returned to prior.
I realize that I was on ADT only for a limited time, however I hope my experience has some value to others.
"Easy does it, but do it", is my mantra.
Best to all.

During my cancer treatment taking Lupron I got to the point that I could barely walk into the hospital. After a month of barely being able to walk went to the doctor, had a Brain MRI and was diagnosed as abnormal gait. Spent ten sessions at physical therapy with no improvement.
Reading online I found that low testosterone.
My cancer was confined to the prostate and started testosterone therapy. The day after my first shot the issue just completely went away. Since taking testosterone I started doing a PSA test every two months and so far so good.
Testosterone is an important part of male bio chemistry and there are negative consequences to suppressing it. I think it is important to balance my quality of life and the risk of TRT

I also went on The Carnivore diet and went from 245 to 185 in six months. Honestly it was easy I could pretty much eat whatever I want as long as it is meat, fish, eggs and cheese
I started lifting weights and at 67 I am healthier than when I was 50