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Lupron: Anyone have muscle weakness and severe leg pain?

Posted by kam23 @kam23, Jul 14, 2023

I have PC and have been on Lupron injections every 3 months for 15 months. I am experiencing severe leg pain in hamstrings and glutes. Has anyone else experienced this or tried monthly shots?

This has been getting worse for the last 3-4 weeks. I’m afraid I’ll be in a wheelchair or have to stop this form of testosterone elimination therapy.

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narus | @narus | Sep 4 11:22am

Testosterone therapy is no so simple as just looking at a number. You need to look at free testosterone, total testosterone, estradoil, Sex Horm Binding Glob, luteinizing hormone. Treatment decisions should be based on symptoms, not just numbers. I take a pretty low dose 10mg/week IM. I have stopped taking it in the past and my issues returned no sex drive, loss of muscle strength in my legs and fatigue.
The negative issue of testosterone therapy is higher hemoglobin and I keep that in check by donating blood.
Maybe I will not live to be 100 but my quality of life is much better.

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oesjipapa | @oesjipapa | Sep 4 6:15am
In reply to @narus "Testosterone gets a bad rap with prostate cancer treatment. It does not cause cancer but will..." + (show)
Profile picture for narus @narus

Testosterone gets a bad rap with prostate cancer treatment. It does not cause cancer but will provide fuel that causes the cancer to grow faster. I have heard the phrase that Testosterone is like rocket fuel for Prostate Cancer I think a better analogy would be Lighter Fuel.
Have you had a Testosterone test?
Six months after radiation and Lupron my Testosterone was about 530 and I felt like crap all the time. After my first dose of T all the problems I was experiencing went away within a couple of days. My Urologist was strongly opposed to the treatment and denied that there was any downside to Lupron Treatment. I got a new Urologist who is agreeable with the treatment and not concerned.
If you take Testosterone your PSA will go up it is part of the biochemical process. I went from a PSA of .1 to .54 but it stabilized there.
Testosterone Is what makes you a man and helps with drive, healthy bones and Muscle development and there are negative consequences to lowering it.
I am 67 and healthier than I have been in a long time I would rather live another ten years healthy and active then 15 in the nursing home.
There are a number of good YouTube videos from Urology seminars that address that address TRT after Prostate cancer.

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@narus Een testosteron gehalte van 530 is toch een normale waarde, omgezet naar Nederlandse waarde is dit bij ons 19 ml/mol en dan wordt het als normale waarde gezien. heb je toch geen extra testosteron nodig.

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dillon5520 | @dillon5520 | Aug 26 8:36pm

I was on lupron every six months for 1 year I complained following the very first injection of the leg pain 10-15 times a day and night lasting 3 minutes. Year 2 they reduced to half dose every 3 months there was some reduction in occurrence but still an issue. Year three on pill form occurrence increased. Treatment ended 9 months ago I continue to experience 10-15 times a day or night is this a rest of my life occurrence I am 82 my PSA is .004
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boki01 | @boki01 | Jul 7 12:27pm
In reply to @beulah4 "I have been on Lupron since June, 2016. I have injections every six months over a..." + (show)
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I have been on Lupron since June, 2016. I have injections every six months over a two year period. This is followed by what my oncologist calls a “Lupron Vacation” until my PSA begins to rise. My doctor says I have had an A+ response to Lupron.
Over the past six months I have begun to experience muscle pain in my thighs and lower legs. Has anyone experienced this reaction?

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Hello,
May I ask what your Gleason score and prostate cancer stage were before you started Lupron treatment?
Wishing you all the best.

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chippydoo | @chippydoo | Jul 7 9:13am
In reply to @maga "No I haven't. What does a foam roller do?" + (show)
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No I haven't. What does a foam roller do?

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@maga Myofascial release. That is the tissue that surrounds your muscles. It can get sticky where two muscles touch. Massage therapist actually get their fingers into the edges which is comfortable but helps with recovery if over worked. The roller can also "roll out" knots in your muscles. Are you by chance taking a statin? Statins can also cause thigh pain.

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Sicetnon3 | @sicernon3 | Jul 6 10:55am
In reply to @beulah4 "I have been on Lupron since June, 2016. I have injections every six months over a..." + (show)
Profile picture for beulah4 @beulah4

I have been on Lupron since June, 2016. I have injections every six months over a two year period. This is followed by what my oncologist calls a “Lupron Vacation” until my PSA begins to rise. My doctor says I have had an A+ response to Lupron.
Over the past six months I have begun to experience muscle pain in my thighs and lower legs. Has anyone experienced this reaction?

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After I quit Lupon , I developed pain in my right shoulder which prompted me to have an c-ray. It revealed mild osteo-arthritis.

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maga | @maga | Jul 6 9:39am
In reply to @beulah4 "I have been on Lupron since June, 2016. I have injections every six months over a..." + (show)
Profile picture for beulah4 @beulah4

I have been on Lupron since June, 2016. I have injections every six months over a two year period. This is followed by what my oncologist calls a “Lupron Vacation” until my PSA begins to rise. My doctor says I have had an A+ response to Lupron.
Over the past six months I have begun to experience muscle pain in my thighs and lower legs. Has anyone experienced this reaction?

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No I haven't. What does a foam roller do?

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1 reply
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guybe | @guybe | Jul 6 6:57am
In reply to @maga "I was on Lupron for 2 years. After the last Lupron injection I started getting leg..." + (show)
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I was on Lupron for 2 years. After the last Lupron injection I started getting leg pain on my left leg. i still have pain after the last injection which was 4 months ago.

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@maga Have you tried a foam roller or massage gun?

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maga | @maga | Jul 5 6:25am
In reply to @beulah4 "I have been on Lupron since June, 2016. I have injections every six months over a..." + (show)
Profile picture for beulah4 @beulah4

I have been on Lupron since June, 2016. I have injections every six months over a two year period. This is followed by what my oncologist calls a “Lupron Vacation” until my PSA begins to rise. My doctor says I have had an A+ response to Lupron.
Over the past six months I have begun to experience muscle pain in my thighs and lower legs. Has anyone experienced this reaction?

Jump to this post

I was on Lupron for 2 years. After the last Lupron injection I started getting leg pain on my left leg. i still have pain after the last injection which was 4 months ago.

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1 reply
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maga | @maga | Jun 26 2:41pm

I aso have a pain that hurts l

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