Lu177-rhPSMA 10.1 Phase 2 Clinical Trial

For anyone interested in doing Lu177 and is chemo naive, you should inquire about this Phase 2 clinical trial. I started October 21, 2025 and have completed 3 treatments so far. My pretreatment PSA was 3.3 and the PSA kinetics was approximately 0.25 weekly. My pre cycle 2 PSA was 2.6 and my pre cycle 3 PSA was 0.6.

Why I decided to enter this clinical trial is primarily due to the location of my mets. I have two positive lymph node Mets; right suprahilar and right paratracheal. These are located where SBRT is very difficult to treatment with external radiation.
The goal is to treat these two observable lymph nodes and also treat any microscopic disease that isn't visible. After 2 treatments, the result is PSA80 and the bi-treatment scans showed a 38% reduction in size(RECIST 1.1 PR).

The rhPSMA 10.1 ligand was shown to be safer than the PSMA-617(pluvicto) ligand in phase 1, that for phase 2 they broke the trial into 2 cohorts and testing front loading the first two cycles.
Cohort 2A is 7 cycles with the first two cycles dosed at 10GB/q and cycles 3-7 dosed at 7.4GB/q. 6 week cycless
Cohort 2B is 7 cycles dosed at 7.4GB/q with the first 2 cycles 3 weeks apart and cycles 3-7 6 weeks.

My RBC, HGb and HCT have been holding up pretty good. I had normal levels before treatment, they drop after each treatment but recovered prior by the end of the cycle so I'm back to normal levels.
AST, ALT and eGFR, creatine haven't been impacted so at the moment kidney and liver are functioning as expected.
I have had no dry mouth at all which is not surprising because the blood clearance rate is much faster than pluvicto.
By participating in this lu177 clinical trial, I can still do pluvicto later without any coverage problems.
When I complete my 7 cycles and my PSA and tumors are no longer detectible, so this is not guaranteed by any stretch, I will pursue Provenge treatment with the hope that by priming the immune system after the lu177 treatments, I can possibly achieve what is called immune equilibrium for a good period of time It's possible in extremely low disease cases but no guarantees.