Losartan 12.5mg

Anyone ever weaned off Lansoprazole 15mg morning and 15mg evening. Any advice welcome

Hi John @bigjohnscho, There is a discussion on Losartan in the Heart Rhythm Conditions group that some members have discussed the drug and might be helpful - https://connect.mayoclinic.org/discussion/losartan-1/. Here's a search of Connect for "weaning off of losartan" that shows a few member posts - https://connect.mayoclinic.org/search/comments/?search=weaning%20off%20of%20losartin.

I also found this warning about stopping Losartan:
"Stopping losartan
Do not stop taking losartan without talking with your doctor. Stopping it suddenly can cause blood pressure to increase quickly. This raises the risk of a heart attack or stroke. If you want to stop taking losartan, talk with your doctor. They will slowly taper the dosage so that you can stop using the drug safely."
-- https://www.medicalnewstoday.com/articles/losartan-oral-tablet#interactions

Have you talked with your doctor on about your concerns?

When I left Mayo Methodist after surgery a year ago, I was advised to stop taking Losartan 100mg per day AND amlodipine IIRC 5mg per day so I stopped both cold turkey. Also stopped Tramadol cold turkey at the same ime. Didn't seem to affect BP much, if at all.

I started Atenolol after taking Losartan because I had a pancreatic attack. Since then I have had no problems with pancreas but I have been wondering if Atenolol could be the culprit of my last diagnosis of small veins neuropathy

I am reading more and more about the link of PPI’s to peripheral neuropathy. I have taken Lansoprazole for many years. I’m getting really concerned. What are your thoughts.

Hello,
I am taking Losartan 12.5 mg but not Lansoprazole PPI. However, if you serach online you'll notice that Losartan actually attenuate the effects of peripheral neuropathy whereas Lansoprazole can affect the condition. Below is something I found online:

Losartan, an angiotensin II receptor blocker (ARB), has shown potential in mitigating neuropathic pain and neuroinflammation associated with peripheral neuropathy. Studies suggest it can attenuate pain and inflammation.

Yes, lansoprazole, a proton pump inhibitor (PPI), has been associated with the potential to affect peripheral neuropathy. While some studies suggest lansoprazole might be protective against certain types of neuropathy, others indicate a potential link to neurological adverse events, including peripheral neuropathy.

Take care and have a serene day,
gus

Thanks. Will discuss with my MD

Has your GP or a registered dietitian screened you for the common nutritional deficiencies that occur secondary to longterm PPI use?

There are Quite a few nutrients that nerves need to stay healthy. Being deficient in any of them is a problem for maintaining structure and functioning of your nerves.

As well it would be informative to know why you are on this medication long term because there is perhaps other treatment options you can try or perhaps the condition you are taking it for may be known to cause neuropathy and that could be addressed.

Just one example of many.

Chronic Pancreatitis is associated with neuropathy. Perhaps because it creates deficiency of fat soluble vitamins like vitamin E that the nerves need to stay healthy . Or because Pancreatitis causes high levels of oxidative stress and inflammation not only to the pancreas but the surrounding tissues and the nervous system too.

And high levels of oxidative stress and inflammation , in order to fight that situation the body churns through high levels of multiple nutrients, like choline to name just one that nerves depend on to stay healthy.

You are going to have to be a bit of a detective to get to the bottom of this and you will also need to find a higher caliber of neurologist. Someone who is actually interested in helping you figure this stuff out.