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Letrozole later onset side effects
I had chemo, surgery and radiation for HER2 stage 2 breast cancer. In March 2024 I was placed in anastrazole, and taken off it in May 2025 due to side effects which I now can’t completely remember. In July 2025 I was then placed on Letrozole and am still taking it. I have suffered from most of the side effects others mention including dry eyes, tendon issues in my wrist, exhaustion, mood changes, a very sore shoulder, etc. I was managing all of this ok, but last week I developed a severe pain in my lower back and it has not gone away. It hurts so much to stand up from sitting, bend over to tie my shoes, pet the dogs, etc. I would like to know if anyone else has experienced this as a late onset side effects others mention and if so, what did you do? I see my oncologist April 8 and would like to provide her with suggestions. Thank you!
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I’m interested in the occurrence of late side effects. I have seen in the literature that this does occur. I have been taking Anastrozole for two years and didn’t develop significant side effects until about three months after starting treatment. I had hoped my side effects had ‘ peaked’ but still struggled on with them. After eighteen months I suddenly began to develop quite severe hand symptoms, which I thought those who experience them usually get fairly early on in therapy. It seems that these drugs are ‘ the gift that keeps on giving’ and. I am just hoping no more ‘ surprises’ pop out of the cupboard!
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1 ReactionNo but I have had back pain. A physical therapist helped me do exercises to strengthen my core and the back pain went away. I would get the pain checked. Could just be something else that can be addressed.