How long do Lupron side effects last after treatment concludes?

Posted by jbuuck @jonbuuck, May 10, 2021

I've been on Lupron for two years. The treatments have ended. How long do the side effects last? Thanks for any insight you can provide.

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I just came off ADT (Lupron & Abiraterone) a week ago after 18 months. I'm not sure what, if anything, I was expecting right away, but my fatigue, anxiety, and depression kicked up this week. After reading the other comments, it appears the side effects of no-T and Lupron are still clear and present. I will say, though, that while my hot flashes during treatment were minor and infrequent, they have really kicked up this past week-I'm more hot than ever and its winter in NY. Something kicked in my depression also, which came about related to cancer, radiation, and ADT- I had never felt it before being diagnosed and treated, or at least on this level. I had been feeling great for awhile (KAT), but things went sideways this week, a noticeable change in energy and drive. Will be #patient. Stay positive guys.

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So wrong Cost in Canadian $ is $3,719 all paid for by Ontario Hospital Insurance plan and free over 65 else private EE ER plans have to kick in about $400 We do pay for OHP monthly below 65 but its a big insurance plan for all Each province has own deal

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My Xtandi cost 3,719 a month CDN and all covered I get now Xgeva foe calcium into the bones 700 every 3 mos injection Back on Zolodex every 3 mos at 1,220 a mos all covered

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@edo

According to my radiation oncologist, hormone therapy does not kill cancer cells. By starving the cancer cells of testosterone, they shrivel and cannot reproduce. This makes them more susceptible to radiation, which damages the DNA irreparably.

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Thank you . I’ve already had salvage radiation without Hormone Therapy. So my next treatment for my recurrence will be Lupron according to my oncologist and urologist. Did not know if it would kill any of the cancer cells.

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@edo

According to my radiation oncologist, hormone therapy does not kill cancer cells. By starving the cancer cells of testosterone, they shrivel and cannot reproduce. This makes them more susceptible to radiation, which damages the DNA irreparably.

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This is exactly what my radiation oncologist said when I asked the same question. So by staying on ADT drugs for a year after radiation is finished, what is accomplished?

Once the radiation therapy is finished, and some time period after while it's still working, isn't this simply postponing the inevitable? You decimate the cells only while your on the drugs, but when you stop, if they are still there undamaged by the radiation....they can start to grow again.

My surgeon prescribed the orgovyx for two years. My RO says 6 mos is a reasonable amount of time. I don't know which one to believe is best at this point. A lot is going to be determined by my next full blood test. If the orgovyx is bringing up liver enzymes and blood sugar etc.. I may stop and see what happens.

Anyone have any experience / knowledge they can share regarding this?

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@lorenbk

There are so many options available for cancer treatment that if one doesn’t work or loses effectiveness, you can try another. Stay positive and do some research. Think of cancer as a chronic disease, not a death sentence.

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I really appreciate this positivizes

I feel great but was concerned after 18 months if it stops working

Stats say 6% chance of living 5 years if distant in bones 30% otherwise

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@firespooks

Just curious. Does Hormone Therapy, kill any cancer cells ?

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According to my radiation oncologist, hormone therapy does not kill cancer cells. By starving the cancer cells of testosterone, they shrivel and cannot reproduce. This makes them more susceptible to radiation, which damages the DNA irreparably.

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Just curious. Does Hormone Therapy, kill any cancer cells ?

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@melcanada

I am on Zolodex injections and now Xtandi or Enzalutamide I have tiredness only I feel positive even though med oncologist said Enza may only last 18 months I have my BP pill then Oatmeal then sake easy to swallow Enzalutamide 4 pills $33.75 CDN each OHIP paid along with a D3 dissolvable

I have green tea with breakfast and throughout the day Soothing I am anxious in the evening though Any thoughts. A tad depressed thinking what's after 18 months?

Jump to this post

There are so many options available for cancer treatment that if one doesn’t work or loses effectiveness, you can try another. Stay positive and do some research. Think of cancer as a chronic disease, not a death sentence.

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@lorenbk

I’m seeing this well after the fact but I have a comment for anyone that might have the same problem. I am in month 7 of Lupron and month 3 of Erleada. I have noticed that anxiety and depression have increased. Having Tourette’s, sometimes my tics are very pronounced. I was reading some studies about Green Tea in the morning reducing anxiety the entire day and found it to be very helpful. When I have green tea right after I get up and before my coffee, breakfast, or whatever, my anxiety, depression, and tics are largely normal for the rest of the day.

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I am on Zolodex injections and now Xtandi or Enzalutamide I have tiredness only I feel positive even though med oncologist said Enza may only last 18 months I have my BP pill then Oatmeal then sake easy to swallow Enzalutamide 4 pills $33.75 CDN each OHIP paid along with a D3 dissolvable

I have green tea with breakfast and throughout the day Soothing I am anxious in the evening though Any thoughts. A tad depressed thinking what's after 18 months?

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