1. < Osteoporosis & Bone Health

Knee replacement and osteoporosis

Posted by lbtw @lbtw, Sep 5 7:59am

I’m just curious if anyone has had a joint replacement during or after osteoporosis treatment? I need a knee replacement and am on Evenity. My endocrinologist would like me to wait six months following my last treatment. I will follow his advice but Of course by then I will be on a new drug. Thanks

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gravity3 | @gravity3 | Sep 5 8:33am

Curious. I just finished my 12 months on Evenity and my endocrinologist said 6 month vacation before starting prolia (not sure yet if I will be comfortable with prolia). I am 76 and had really great results with evenity. How long is your vacation and did you have good results and what will your next drug be? Thanks

REPLY
anne905 | @anne905 | Sep 6 9:40am

I need a knee replacement and am taking Prolia, and the thought of a challenge hadn’t occurred to me! Though I hadn’t thought to mention an osteoporosis drug to my Orthopedist, nor my need for a knee replacement with my Endocrinologist.

Prolia is the only osteoporosis drug I tolerate. I’ve never had a challenge and just had my 5th injection, after having stopped to try Evenity and then Tymlos to build bone, I’ve returned to Prolia. I’m 63, and am told I’ll be on it for the rest of my life, because the ‘bone builders’ caused severe side effects.

In researching, I found the following research study finding that Denosumab (Prolia), actually is beneficial with knee replacements specifically!
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434591/
Interpretation

Denosumab reduces early migration in total knee replacement, as in previous trials using bisphosphonates. As migration is related to the risk of late loosening, denosumab may be beneficial for long-term results.

REPLY
1 reply
findtheanswersdn | @findtheanswersdn | Sep 6 9:54am
In reply to @anne905 "I need a knee replacement and am taking Prolia, and the thought of a challenge hadn’t..." + (show)
@anne905

I need a knee replacement and am taking Prolia, and the thought of a challenge hadn’t occurred to me! Though I hadn’t thought to mention an osteoporosis drug to my Orthopedist, nor my need for a knee replacement with my Endocrinologist.

Prolia is the only osteoporosis drug I tolerate. I’ve never had a challenge and just had my 5th injection, after having stopped to try Evenity and then Tymlos to build bone, I’ve returned to Prolia. I’m 63, and am told I’ll be on it for the rest of my life, because the ‘bone builders’ caused severe side effects.

In researching, I found the following research study finding that Denosumab (Prolia), actually is beneficial with knee replacements specifically!
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434591/
Interpretation

Denosumab reduces early migration in total knee replacement, as in previous trials using bisphosphonates. As migration is related to the risk of late loosening, denosumab may be beneficial for long-term results.

Jump to this post

do you have any side effects from Prolia? I've read them that can happen? pretty awful been afraid to take this,,?

REPLY
1 reply
anne905 | @anne905 | Sep 7 9:26pm
In reply to @findtheanswersdn "do you have any side effects from Prolia? I've read them that can happen? pretty awful..." + (show)
@findtheanswersdn

do you have any side effects from Prolia? I've read them that can happen? pretty awful been afraid to take this,,?

Jump to this post

Nope. I’ve not had any side effects with Prolia, and hope the never happens. My endocrinologist said they’ve never had any of their patients experience any side effects from Prolia, which made me feel better about starting it. I can’t take anything else. Tried it all, and experienced negative side effects, so Prolia is all I’ve got. I’ll be on it the rest of my life.

REPLY
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