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Issues with ProACT incontinence value
For those that are not familiar with ProACT. It is used to aid in reducing incontinence and works quite well. It is something like the artificial urinary sphincter. (AUS) but doesn’t require you to push a button to pee.
Last week I attended a presentation by a urologist who specializes in incontinence. He discussed a lot of different issues, of course, but his experience with products that didn’t work, as well as expected, was very informative.
I know that the urologist I have gone to has said that, even though I’ve had radiation, she would consider using the sling. She was not using. ProACT yet but they were planning on starting to use it.
The Doctor who was doing the presentation had started using ProACT when it first came out. He used it on a lot of patients that would’ve gotten an AUS because he thought it would work just as well, but be easier on the patient. As for the slang, he confirmed that it frequently doesn’t work well for patients who had radiation.
Unfortunately, he found out that the way the ProACT worked was not compatible with people who had radiation. ProACT works by placing two balloons near where your prostate was and they squeeze on the urethra to stop it from leaking. When someone has radiation, it makes the urethra stiffer and as a result ProACT doesn’t work well.
It seems that the only solution to a serious problem of incontinence is the AUS. New models seem to be much smaller.
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Thanks Jeff. This is informative. I had SBRT. I didn't experience incontinence as an immediate side effect, and I'm hoping to not have it as a long term SE, else I will consider AUS.
Jeff, is there a way that I can find a reply you made to me that I found very helpful?
I struggle navigating around this forum.
You replied to me in July or August
Thanks
PS it says that I can PM you but when I click on it it says “ page not found “
If you go to the top level of the prostate cancer forum, there is a search bar there that may enable you to find what you’re looking for.
Did you reply to me about that Or did you like it or say it was helpful? I can look those up in my email pretty easily if you have done that.
On 7/28 you did reply to two comments I made. Was either one of these what you’re talking about?
Reply by @olman to a comment you posted on discussion "Is there an average and/or an expected drop in PSA after Lupron shot?"
@olman posted a new reply to your comment "Did they say it was in your seminal Vesicles? That would make it more aggressive. Actually,..."
To the best of my recollect you mentioned a drug that would seek out cancer cells and kill them. It was perhaps in addition to my ADT drug. I thought you suggested that I ask my oncologist about adding it my abipaterone, prednisone, and climax.
I thought I wrote it down but have not found it since
Any idea what drug it is?
I mentioned a new drug being studied that would seek out dormant and alive cancer cells and kill them.
It is called PROTAC ARV-766
Here’s some info on the study
https://ascopubs.org/doi/10.1200/JCO.2023.41.6_suppl.TPS290
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1 ReactionRead the article and got the impression that this drug is NOT a radio pharmaceutical drug like Pluvicto. Is that correct?
Updated: I read the following about this drug - ARV-766, also known as luxdegalutamide, is an investigational oral drug developed by Arvinas for the treatment of metastatic castration-resistant prostate cancer (mCRPC). It belongs to a class of drugs called proteolysis-targeting chimeras (PROTACs), which are designed to selectively degrade specific proteins within cells.
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1 ReactionYou know as much about it as I do. There was a precursor to this drug that never got anywhere, but was quite promising (Protac ARV-110), PROTAC ARV-766 advanced the development further.
I guess AI is about the only place you can find more information about this. Do searches on the web about that drug name and you will see most of the information that is available.
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2 ReactionsThat looks as I recall seeing it.
Now I’m enjoying reading replies to you and the study you linked
The way info travels here give me opportunity to as my oncologist. Depending if Jekyll or Hyde shows up there exists an opportunity to speak to a Doctor, VERY RESPECTED in the field of PC oncology. If he knows about this drug and he’s in THE GOOD MOOD he’ll engage me in an intellectual discussion
If he 1 didn’t sleep well or if a resent double hip replacement and his personal philosophy on PAIN MEDS sympathy and empathy isn’t enough to bring a smile to his face. I listen and he share his pain. I make him laugh from time to time with “ we got this Doc with an arm around his shoulders or a light fist bump; something about TREATING him like “ one of the guys “ tickles his funny brain ( like a funny bone but in the head so I’m thinking it might be a MENSA inside joke. Great to hear him laugh but at times he laughs too fast then he starts choking… then I lightly pat him on the back. I’ve printed up a bill that I plan on handing to him with charges for services rendered. The charge: a🦌too98
PS this is a side effect of one of the drugs you gave me or maybe it’s the new 🌻that I procured from the dispensary
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