Is weight loss in Stage 1, Gleason score of 6 cancer, normal?

Everyone reacts differently to learning that they have prostate cancer. A Gleason score 6 means a low-grade cancer that is likely confined to his prostate and, therefore, is curable. Some people do lose weight during this stage when they change their diet. I would encourage him to read Dr Patrick Walsh's book, Guide to Surviving Prostate Cancer, and look at the online material at PCF.org and PCRI.org for Gleason 6 prostate cancer. You will find that exercising and a healthy diet are recommended both to help with stress reduction (along with other stress reduction techniques) and to prepare for any future treatments that he may choose. Lastly, he is very fortunate to have you as a partner that is helping him through this journey.

Prostate cancer, when detected early, is usually asymptomatic. Has he had any other bloodwork done (CBC and CMP) to look for any other users that might be indicators of his recent weight loss?
By the recommendation to “be monitored,” I assume you mean “active surveillance?” The reason for active surveillance for Grade Group 1 is that there is some debate in the medical community as to whether a true 6(3+3) is actually cancer. Some in the medical community say that since a “3” cell structure can’t metastasize it shouldn’t be considered as a G7+. (That it’s a harmless lesion - that it shouldn’t necessarily be actively treated.) Active surveillance is almost always called for with a 6(3+3) unless there are other known risk factors.
You mentioned his Gleason score; did he also have an MRI? If so, what were those results?
Does he have any other factors that might indicate higher risk?: 1st degree relative with prostate cancer, African-American descent, Ashkenazi Jewish descent, low PSA Doubling Time, high PSA Velocity, low % Free PSA, high PSA Density, negative biomarker (genomic) test results, or negative genetic (germline or somatic) test results.
For now, if it were me I would not worry (much), and follow all the test numbers closely, monitoring them for any problematic trend.
(I was on active surveillance with a 6(3+3) for over 8 years. When we eventually saw a Gleason 7, it was then that I had active treatment.)

Thank you so much this is good advice...hadn't even occurred to me yet to get a good book. I will get it tomorrow, and look up the other online material too...and thank you for kind comment to me..but he gives me so much support too, and I know he wants to do more..when he can..because I realize that anyone of us can get cancer, or just be alone and need someone as a dedicated partner. Wishing you peace in your journeys.

Thank you for sharing and educating me more. We haven't had any blood tests (CBC and CMP) that I know of, but we meet with the surgeon who did the transperineal biopsy next month. He had his MRI few weeks ago. BTW, this forum is so helpful, it is the ONLY reason that he got a transperineal biopsy instead of the transrectum. I read two different people told me to ensure he got the transperineal and I researched and understood the reason. However, when my parter was scheduled, no one asked him what type he was getting, he was just told he was getting a transrectal biopsy. On the day of the procedure, only because Mayo Clinic advice, we asked the surgeon to do the transperineal, and he said "sure" like it was nothing, but he even admitted the rate of bacterial infection was lower with the transperineal. Anyway, I am so grateful for the knowledge everyone is sharing.

Yes, you are right it's active surveillance, which I really don't know what that means yet..biopsys? annually? My partner does have familial prostrate cancer (pc). His maternal grandfather died of it and his maternal uncle (mother's brother) died of pc in his 40s, and my partner is African American, so there are other risk factors. But right now he feels fine, no pain, and he has a huge appetite despite losing the weight..so we think maybe it is weight loss due to the stress..

We will let you know..btw I am sorry that your Gleason score rose to 7..so then what kind of active treatment did you have to get at 7? Wishing you peace, take care.

Here is Johns Hopkins’ protocol for active surveillance: https://www.hopkinsmedicine.org/health/conditions-and-diseases/prostate-cancer/active-surveillance-for-prostate-cancer

That’s close to what I did: PSA tests every 4-6 months; repeat biopsies every 2-1/4 years.

Those nearly 9 years on active surveillance gave me time to thoroughly evaluate all treatment options and pick the one that was right for me - proton beam radiation. The plan was to not get active treatment until it was medically necessary. Gleason 7 is that point. The proton radiation treatments were relatively uneventful and I’ve had no lingering after-effects.

I’m now 3 years out since completion of proton radiation treatments. My wife later told me that if she hadn’t known I was undergoing radiation treatments, she wouldn’t have realized it from any change in me. (If I’m happy with the outcome, and she’s happy with the outcome, and our emotional/physical relationship is still solid, that’s a trifecta I can live with.)

With his family history of PCa, he should see if his doctor can order (and his insurance company will pay for) a genetic (germline) test to check for gene mutations. He may (or may not) have inherited any. If he can’t get the genetic test from his doctor or his insurance company won’t pay for it, he can get a free genetic test here: https://www.prostatecancerpromise.org/

I’m African-American. I’ve found that every test, diagnostics, treatment that I’ve had, has worked for me just as with anyone else. He should keep following standard protocol and not let anyone change his focus.

Once I decided on active treatment, every time I’ve done a PSA test, we’ve also tested testosterone levels and included CBC & CMP; every time. In fact, just this morning I had all those tests done.

wow..I am really impressed on how you have taken the lead in your understanding of your own medical situation, so that it opens up choices that you may not have known about..I'm also happy you have gone so many years with just active surveillance, and even though you rose to Gleason 7, the additional treatment hasn't seemed to impact the quality of your life. You shared a tremendous amount of valuable information. My partner is now a part of this forum, so he is likely reading your response too, and he hopefully will take all of your information and use it to his benefit. Wishing you and loved ones the best life ahead every day. Thank you again for sharing.

I am truly grateful for this forum and the wealth of experiences and information shared. I am @tinamaria1's partner. I am not one who openly shares on forums, but your willingness to do so has made a tremendous difference in my treatment and that which is to come. Thank you.

Welcome, @owens2732. I'm so glad that @tinamaria1 took the plunge and asked some questions on your behalf. I'm used to the supportive and informative posts that members make on this forum, but it never ceases to amaze me. The responses from @brianjarvis and @jsh327 hit the high watermark, didn't they?

Be sure to let your cancer team know how Mayo Clinic Connect helped support you so they'll in turn continue to tell others about the group here.

Owen's did you do genetic testing to discover that your have familial prostate cancer? Did you have the testing prior to the diagnosis?