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orgovix 120 & zytiga 1000 but PSA went from 12 to 19 in 9 mo. now what?
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orgovix 120 & zytiga 1000 but PSA went from 12 to 19 in 9 mo. now what?
Interested in more discussions like this? Go to the Prostate Cancer Support Group.
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Hi Duberdicus.
Replies to your question will be much more helpful if you share the details of your diagnosis, biopsies and treatments to date including Gleason and Decipher results.
Welcome to MCC!
Bill
treatment started in 2015:
radiation and ADT.
Ups and downs until 2024 ADT no longer worked.
2025 PSMA showed spine, spinal column, ribs, pelvic bone, pelvic wall, lymph nodes, iliac all involved.
started orgovix and zytiga but PSA continues to rise 12 to 19 in 9 months.
You need a PSMA pet scan. That can find a metastasis somewhere in your body usually. You need whatever’s causing that rise in PSA to be zapped so that you can get back to normal again? You really need to discuss this with your doctor and try to get this test.
There really isn’t any other way to find What is causing your rise in PSA.
The drugs you are on should have dropped your PSA down, to undetectable, The fact that it didn’t drop means that there’s definitely a metastasis or multiple metastasis somewhere.
This is discussed in the PCRI conferences. Some of the doctors strongly believe in just waiting for the PSA to rise finding the metastasis and zapping them. That can get you back to normal.
Chemotherapy or Pluvicto Are two other options, but they normally have to find metastasis using the PSMA PET scan before they will do those procedures.