Irreversible electroporation (IRE)?

I personally know several associates here in Canada who have had IRE - the NanoKnife procedure , All were very successful . An approximately 1-2 hour treatment , and home the same day . Minimaal to zero side effects .
See Professor Dr. Emerton , Kings College Hospital in London, England , video on NanoKnife . Multiple locations in Canada are performing this procedure -- many are in Toronto . One of my associates went to a clinic in Germany where they have performed thousands of NanoKnife procedures .
It is a growing treatment worldwidee -- slower in the USA for some unexplained reason . It's currently far outpacing TULSA-PRO.

I just saw this summary article on UroToday, which was recommended to me by @kujhawk1978 if I remember correctly. Often the articles here relate more to advanced treatments, but this was a "state of the profession" summary of focal therapies, which include IRE, TulsaPro, and a variety of others. Here is the link--I'm not sure if it works for anyone, but if it doesn't you might need to sign up or something. https://www.urotoday.com/conference-highlights/2024-south-central-section/155939-scs-aua-2024-focal-therapy-in-prostate-cancer.html
Here is the closing summary:
Dr. Meng concluded his presentation by discussing focal therapy in prostate cancer with the following take-home points:
-Focal therapy is an important tool in our armamentarium for treating prostate cancer
-There are multiple energy sources available, but overall oncologic outcomes are similar
-Focal therapy allows good preservation of continence and decent preservation of potency
-There is significant patient interest in focal therapy options, but patient selection is critical

Statistically, the statement was made: "Among patients with mostly intermediate risk disease, at 1 year 80% of patients have no significant disease, however, at 5 years 21% of patients may have to undergo an additional intervention for prostate cancer." This is a little weird, since the time frames are different but the percentages are almost symmetrical, but anyway, I get the drift. It puts off more radical treatment for most of the people for a meaningful amount of time.

The summary also makes the point that it is attractive because it provides an intermediate path between active surveillance and radical treatment, whether by radiation or surgery or both. I think that has been amply reflected in these forums over the few years I've been following them.

I think it relates to this discussion as it also helps to see how the specific pattern of identified cancer in the prostate contributes to the informed selection of which focal therapy (i.e., selective ablation or killing of cells) fits what is known about a particular presentation of cancer in the individual.