Immunotherapy with Clear Cell Carcinoma- Endometrial

Posted by carla702 @carla702, Nov 10, 2022

I am Stage IV clear cell endometrial carcinoma with metastases to bone. My biopsy results including MMR testing indicated that I am not a strong candidate for immunotherapy (pMMR, normal DNA mismatch). I started on Carbo-Taxol right away. But I have also heard that CC cancer is chemo-resistant. And recent studies say that Keytruda is effective regardless of MMR results.
Has anyone with endometrial cancer had Keytruda/immunotherapy as a first-line treatment or was chemo prescribed first before immunotherapy was offered?

Interested in more discussions like this? Go to the Gynecologic Cancers Support Group.

sm22 | @sm22 | Nov 14, 2022

Hello- I am also battling clear cell endometrial cancer and had a terrible reaction to Taxol. I have heard that CC is somewhat chemo-resistant as well. I am trying to find out more info about CC and Keytruda but there is limited info about this type of cancer so it does get frustrating. Take care-

Helen, Volunteer Mentor | @naturegirl5 | Nov 13, 2022

@carla702
I personally do not have experience with metastatic endometrial cancer and immunotherapy. I wanted to jump in and let you know that you will receive lots of support here in our group. @colleenyoung tagged members of our group who will be offering their stories and support for you.

I'm glad to know you are tolerating the chemo fairly well. When is your next infusion and when will you have the PET scan?

carla702 | @carla702 | Nov 12, 2022

In reply to @colleenyoung "@carla702 I believe fellow members like @miriam57 @rainna @stayinghopeful @m1b1r9 @glenda007 @mnmimi @ejohn may have experience..." + (show)

Hi @colleenyoung thank you for those references.
I am tolerating chemo fairly well. Anxious to see from PET scan
how effective it has been.

Colleen Young, Connect Director | @colleenyoung | Nov 10, 2022

@carla702 I believe fellow members like @miriam57 @rainna @stayinghopeful @m1b1r9 @glenda007 @mnmimi @ejohn may have experience with immunotherapy and metastatic endometrial cancer, in particular with Keytruda and clear cell type of endometrial cancer. They may be able to share if it was given as a first-line treatment after chemo.

You may also be interested in this related discussion.
- Anyone living with metastatic endometrial Cancer? What treatments? https://connect.mayoclinic.org/discussion/anyone-living-with-metastatic-endometrial-cancer/

Carla, how are you doing on Carbo-Taxol?

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