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Concerned about the side effects of anastrozole

Posted by tinalove @tinalove, Jan 31, 2016

I completed all treatments for breast cancer but now I am supposed to take hormone blocker, named anastrozole. im concerned about the side effects. Has anyone here taken it and did anyone have hair loss?

Interested in more discussions like this? Go to the Breast Cancer Support Group.

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hopeful64 | @hopeful64 | Jan 10, 2023
In reply to @micheleandrew "I'm grateful I found this MayoClinic community! I am 52 years old, had bc twice -..." + (show)
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I'm grateful I found this MayoClinic community! I am 52 years old, had bc twice - in 2010 and more recently stage 1 in 2020. My younger sister had it at 33 years and is doing well, no longer in treatment. I was on Tamoxifen in 2010, and now taking Zolodex (to put me into menopause) and now taking Anastrozole since 2020. I'm not sure I can take the side effects any more. I'm meeting with my oncologist next week for my 6 mos. visit. I was told the symptoms after a few months would stabilize. It's almost 2 years, I have osteopenia, but the fatigue, sleep issues and joint pain (wrists, hands, knees) and brain fog are rough. I have two teenage sons who keep me on my toes! I have a hard time working (I am a remote therapist), sitting down after extended time just makes me achy. When I'm up and moving around and don't need to focus - I'm okay. I am going to ask my dr. about my case and recurrence risk. My Dr. and team make it sound like those with side effects are not the norm - but the Infusion nurse (who happens to also be a bc survivor) tells me that all of the bc patients she sees complains of the hormone treatments (AIs) and she had to stop herself, she was so miserable. I guess it's nice to know I'm not alone. I'm tired of explaining myself to my friends, etc. who wonder why I more flaky these days - I simply don't have the energy and feel that great some days. I suppose if you haven't been there, it's hard to imagine because they think I'm done and on the other side. Thanks for listening.

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Wow! thanks so much for sharing. I have been on Anastrozole for about 7 months. I recently just started having aches in my wrist where I could barely move it without pain. I thought it was just the sign of getting old ( I am 64) . However the joint pain has been increasingly worst. I too exercise and walk, which seems to help.

What is almost unbearable is the anxiety and depression. Is anyone else going through this?

Note: I am new to this site and I honestly never thought I would participate. But after reading many of your stories it has really helped me a loth. Thank you all!

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michelleoj | @michelleoj | Jan 9, 2023
In reply to @floramart "What kind of skin issues are you dealing with? I have been dealing with hive like..." + (show)
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What kind of skin issues are you dealing with? I have been dealing with hive like welts and itchy rash on my radiated skin. I even got a shingles test to rule that out.

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I’m having the same issue but it spread from my surgery scar to my whole body. I’ve been off anastrozole for a month and they can’t control the hives . They took me off of it because after one month, I could hardly walk or move my hands because of joint pain and I was very depressed. Pain and depression resolved but not the rash.

I’m supposed to start tamoxifen

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windyshores | @windyshores | Nov 26, 2022
In reply to @polianad22 "Hello beautiful ladies, I would like to know if you still need to do hormonal treatment..." + (show)
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Hello beautiful ladies,

I would like to know if you still need to do hormonal treatment if you have double mastectomy. Please share your thoughts. Thank you.

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Yes for hormone-positive cancers, hormonal meds are recommended. You do not remove all risk by removing breasts.

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polianad22 | @polianad22 | Nov 26, 2022

Hello beautiful ladies,

I would like to know if you still need to do hormonal treatment if you have double mastectomy. Please share your thoughts. Thank you.

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windyshores | @windyshores | Nov 11, 2022
In reply to @windyshores "@kchiavetta86 I am responding to the 2022 study that you posted first. Please note that the..." + (show)
Profile picture for windyshores @windyshores

@kchiavetta86 I am responding to the 2022 study that you posted first. Please note that the quote that you highlighted concerning evaluation of memory and other cognition pertains to chemo, not aromatase inhibitors like anastrazole:

"The FACT-Cog is a self-assessment questionnaire to estimate memory, attention, concentration, language, and thinking abilities of patients before, during, and after chemotherapy. "

I have read about this study. The study controls for the effects of chemo and of cancer itself (for depression and anxiety for example) in order to more accurately attribute side effects to AI's.

The various side effects are being investigated by the study but that does not mean they are common. They are hypothetical for the study.

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Concerning the 2015 study, which has been posted recently by someone else, I urge people to read the entire link. Clearly better studies were needed and are now being done.

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windyshores | @windyshores | Nov 11, 2022

@kchiavetta86 I am responding to the 2022 study that you posted first. Please note that the quote that you highlighted concerning evaluation of memory and other cognition pertains to chemo, not aromatase inhibitors like anastrazole:

"The FACT-Cog is a self-assessment questionnaire to estimate memory, attention, concentration, language, and thinking abilities of patients before, during, and after chemotherapy. "

I have read about this study. The study controls for the effects of chemo and of cancer itself (for depression and anxiety for example) in order to more accurately attribute side effects to AI's.

The various side effects are being investigated by the study but that does not mean they are common. They are hypothetical for the study.

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anjalima | @anjalima | Nov 11, 2022
In reply to @tenayalake86 "This is a recent study. I'm trying to find other sources to post here. If I..." + (show)
Profile picture for Tenaya_Lake @tenayalake86

This is a recent study. I'm trying to find other sources to post here. If I find others, I will let you know.
https://clinicaltrials.gov/ct2/show/study/NCT05297617?term=arimidex+and+memory+loss&draw=2&rank=1

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Time to kick up the meditation practice which in addition to reducing stress, expands the cognitive function of the brain.

I’m all into mitigating!

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anjalima | @anjalima | Nov 11, 2022
In reply to @tenayalake86 "This is a recent study. I'm trying to find other sources to post here. If I..." + (show)
Profile picture for Tenaya_Lake @tenayalake86

This is a recent study. I'm trying to find other sources to post here. If I find others, I will let you know.
https://clinicaltrials.gov/ct2/show/study/NCT05297617?term=arimidex+and+memory+loss&draw=2&rank=1

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I’ll get started here. Thank you.

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Tenaya_Lake | @tenayalake86 | Nov 11, 2022
In reply to @anjalima "Could you point me to information about cognitive and memory loss. I have not come across..." + (show)
Profile picture for anjalima @anjalima

Could you point me to information about cognitive and memory loss. I have not come across this one in my research travels. That is obviously concerning and I would like to learn more about it. I will discuss with oncologist also. Thank you.

Glad you are tolerating AI well in case you decide to stay the course.

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This is a recent study. I'm trying to find other sources to post here. If I find others, I will let you know.
https://clinicaltrials.gov/ct2/show/study/NCT05297617?term=arimidex+and+memory+loss&draw=2&rank=1

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