Concerned about the side effects of anastrozole

It is so complicated! I took have osteopenia and on Anastrozole. I had Prolia shots in 2019 and massive dental work in early 2021. Luckily everything went well.
I had been in fosamax in earlier years, but my jaw bone was good.
So many things we have to balance now that I never worried about before. I understand what you are saying.
Right now for me it's fatigue. Really struggling.

I thought Tamoxifen is prescribed for premeopause women...

Thanks, Flowergal. I review at WeeklyWilson.com and also on TheMovieBlog.com,
I've been reviewing film (a sidelight, as I taught and had "real" jobs, too) since 1970, first starting out in the real newspaper (Quad City Times, Davenport, Iowa.) In fact, I compiled my reviews from that paper in a book entitled "It Came from the 70s: From The Godfather to Apocalypse Now." (available on Amazon with 10 trivia questions per film, with the answers upside-down on the next page.)
I have covered the Chicago International Film Festival for over 20 years and have done SXSW since about 2015 and also, over the years, have been Press at Sundance and the Vancouver Film Festival and in Denver, Nashville, and others (Windy City Film Festival, but that time I was a finalist in the screenplay competition.) The injury to my left knee was devastating for SXSW last year, but they were very kind to me, and, somehow, I made it through the continuous standing that occurs when you are waiting for the "stars" to show up. I hope to be able to continue reviewing, as I have for 52 straight years, for the forseeable future. I also write "long" on occasion and those works (30+) are up on ConnieCWilson.com. To say that I found being in a wheelchair for over half a year inconvenient is putting it mildly. Would any of us want to be unable to take ourselves to the bathroom? Is that the price I must pay to "protect" myself against a recurrence---being semi-crippled? It's not even a guarantee of protection and it's too steep a price to pay. As for the Tamoxifen, my good friend Sue Ann Raymond (now 84) had her lumpectomy in 2013 and was put on Tamoxifen and described how she could not even get out of bed! Sue Ann is an Episcopalian minister in small-town Iowa and she simply pushed the pills back on the oncologist's desk and said, "It's in God's hands." Since then, she has shepherded her flock, jumped out of an airplane to raise money for a new roof, and been approached to run for Mayor. None of those things would have been possible if she had remained on Tamoxifen back in 2013 when it was prescribed to "protect" her. It really is a "risks versus benefits" thing, and, while I am justifiably apprehensive, I practice what I call Eternal Vigilance and try to push thoughts of my demise to the back corners of my over-active imagination. I'm in Austin (Tx) right now, planning our annual trek back to Illinois to avoid the heat of summer and thinking about "writing long" again with a 4th book in my 3-book series "The Color of Evil." I'll be attending the Rolling Stones concert at Soldier Field on June 27 and, in the 3 days after that, the Sundance films are being shown in Chicago for 3 days (although I reviewed most of the winners on my WeeklyWilson blog already.) As I have written elsewhere, my mother---a 4-shots-a-day diabetic---lived to be almost 96 and played bridge ALL the time (once flying to Hawaii to play in a tournament that Omar Sharif played in!). I'm not about to quit living life, nor am I willing to suffer the tortures of the damned on the off chance that these toxic substances might "protect" me somehow. I'm going to be trying to find out about any other clinical trials of the sort explained here:
https://www.icr.ac.uk/news-archive/research-uncovers-how-to-target-sleeping-breast-cancer-cells-and-prevent-relapse

I had osteopaenia going in to treatment, and my experience(s) while on Anastrozole for 7 months, including my left knee totally blowing out and putting me in a wheelchair for 6 months, has led me to the very likely conclusion that the knee collapse (of an already fragile joint) was exacerbated by Anastrozole. I started out with the intention of being treated, start to finish, by Genesis in Davenport, given very bad interactions at Trinity in Moline since 2018. I wouldn't even go to Trinity for a simple mammogram after 2018, but the pandemic upended my plans to avoid the Illinois side of the river and the 33 radiation treatments I was told I needed, which was a fairly lengthy process, as you can imagine, did not help, so, having been told that I didn't even need an oncotype, I interpreted that to mean that my b.c. was a garden variety tumor that could just as easily be treated locally. Not sure that was a wise decision, but it is why I ended up back at Trinity and not at Genesis, where I had already selected a surgeon (Dr. Hartmann), who, among other pandemic crises, totally disappeared without a word to the patient(s) as to where he had gone or when he would be back. (It was very weird that those of us whom he was supposed to operate on were not told anything about the sudden cessation of his office. Since I had done some reading on optimal times to have surgery and knew that simply "hanging around" for months wasn't ideal, I tried to be positive and gave in to the idea of going to the much-closer Trinity for the radiation, despite bad experiences there during a breast biopsy in 2018. The reason I have not gone forward with more active treatment for bone loss is that I am "borderline" currently and the discussion(s) on taking biphosphanates (among other things) and on the veracity of Dexa scans are everywhere. With a T score of -2.2T currently, I filled, but did not take, such a pill. It was prescribed me by my endocrinology team at my request. I was told to step up my calcium intake (with D and K) and did. (There is some information out there about whether or not an uptake in calcium can contribute to heart attacks and strokes, so taking 600 mg. in the morning and 600 mg. at night is about all I've done, so far. My next trip in to see the endocrinology team is in early May. Meanwhile, I've been locked into major dental work ($10,000) since November and was glad I could truthfully say I had not taken the biphosphanates that they feared might weaken my jawbone prior to their implant procedures.

Tamoxifen will not "inflame" the joints as the A.I. drugs do. And I AM "old," as my doctor so tactfully pointed out, With any luck, we will both get even "older." My mother---a 4-shots-a-day diabetic---lived to be 96 with no dementia and played bridge until almost the day she died. (She once flew to Hawaii to play in a tournament that Omar Sharif was playing in). I always figured I'd get diabetes, so I began watching out for that a long time ago, but the b.c. cancer diagnosis came from out of left field and left me totally unprepared. Like my mother, I am a fighter, and I won't go down without a fight, for sure. I feel normal and fine right now and, since I stopped taking all pills to "protect" me my energy levels have returned and I have recently done the Chicago International Film Festival, Nashville, Sundance, and, just recently, SXSW. I filed 34 different reviews from Austin in 8 days, attending 3 movies a day and writing until (sometimes) 4 movies a day. (I enjoyed telling my friends that I might get to meet Ryan Gosling on March 10th if I got the Red Carpet for that one) Not being able to stand (or walk) is not something that I can live with, and the Anastrozole definitely put me in a world of hurt in so many ways. Just for the World Premiere of "Stormy" (the documentary now showing on Paramount Plus, I think, I had to stand from 3:15 until 5:30 p.m. waiting for her to show up. I post on my own blog (WeeklyWilson) and on TheMovieBlog and have been reviewing film non-stop since 1972. I have no intention of letting cancer stop that, but it sure put a crimp in my style last year when I could neither stand nor walk.

Rozv, your experiences on Anastrozole mirror my own. I also tried Tamoxifen, and can attest that it is easier to tolerate than Anastrozole, but when I was told I HAD to step up my intake from 10 mg. to 20. mg., things went South for me. I was on 10 mg. from April 23, 2023 until June 23, 2023. I had told my Texas oncologist that I was only going to take 10 mg. (not 20) and the reason was the Italian Women's Study of 700 Italian women who took a reduced dosage. I actually was only taking the 10 mg. every other day, so my total weekly consumption was 40 mg. On this dosage I experienced dryness and a constant urge to urinate. Nothing felt normal from the waist down, but I did not have the extreme fatigue or the UTIs that I experienced once I moved up from the 40 mg. a week to 140 a week. I was told by my Texas doctor's office that my faith in the Italian Women's Study was misplaced, because I was comparing apples to oranges in that their tumors were "in situ" and mine had broken through. Therefore, I agreed to step up to 20 mg. daily and that was NOT a good idea for me. I immediately had EXTREME fatigue. I could only be up for 3 hours at a stretch. I began having what felt like UTI infections and they were not able to be quelled by Amoxicillin or another strong drug prescribed by my physician. (I also tried something OTC that did nothing but turn my pee orange). This started before New Year's Eve and, after 10 days of this constant burning and itching and urinating I was headed to the convenient care when it dawned on me that I should probably call, instead, the OB/GYN my oncologist had made me get an appointment with, to keep tabs on the possibility of a thickening of the uterus (uterine cancer symptom) from Tamoxifen. I had been on her appointment calendar for 9 months. She refused to see me and I was reduced to tears, while driving to the convenient care facility. Her scheduling person called me back and told me to call my oncologist, which I did. He had me drive to another town and leave a urine specimen and that was when and how I got the second strong antibiotic. The 2 strong antibiotics then turned into a fungal infection, which also required medication and an office visit. I quit taking everything on Aug. 30, 2023. Am I concerned that I might have a recurrence since my onco score was 29. Of course, but I can't say that having non-stop UTI infections is a good trade-off, since I have a good friend who died from one that went septic. (As did the former Charlie's Angels star who died at 65 from one.https://www.womenshealthmag.com/health/a35155137/actress-tanya-roberts-death-urinary-tract-infection/).

So, my choices are: to take Anastrozole and be wheelchair bound and suffer agonizing joint pain OR risk endometrial cancer or a blood clot or sepsis, as described above.

When you need "protection" from the "protection" it is time to take stock and analyze the risks versus the benefits, which is what I have done at the ripe old age of 78.

I hope you will get the care you deserve with your new doctors.