How long do the hot flashes last? Another 3 month Eligard shot today

Posted by greg52 @greg52, Nov 26, 2024

Hello all. I have completed my 5 1/2 weeks of EBRT for intermediate risk prostate cancer and had first injection of Eligard 3 months ago.

Gleason 7, Stage 2, PSA 8.9. 9 of 17 cores positive. Decipher 0.69.

I am scheduled to get my second 3-month injection of Eligard today.
I must say the hot flashes have been bothersome. I'm waking up every several times a night sweating and multiple annoying hot flashes throughout the day.
Just difficult to sign up for ANOTHER minimum of 3 months of these hot flashes. Haven't had a shot in 3 months and still having as many hot flashes when I first started.
As I wait for injection appointment which is only a couple hours away, I find myself searching for recurrence/mortality rates for those that forgo the second 3 month shot.

I understand there are others that are dealing with much worse than I am so don't mean to be insensitive.

I will continue to search for other posts on this topic but just curious what input/advice others might have.

Thanks to all.

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

I have had the same experience. My oncologist prescribed effexor to help control hot flashes, and it did help cut my hot flashes by at least half. One side effect of Effexor is diarrhea, and that was the reason I eventually discontinued effexor.

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Profile picture for jeff Marchi @jeffmarc

A doctor at one of the conferences I attended recently said that he reduced the fatigue by increasing the prednisone from 5 mg to 7 1/2 mg. I know someone else that increased it to 10 mg and it worked for them. Ask your doctor.

Getting a lot of exercise is supposed to help in reducing the fatigue as well. Weight training and walking daily can really help, and they also offset the deterioration of your muscles that occurs when you’re on Zytiga and Lupron.

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Test

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Profile picture for northoftheborder @northoftheborder

+1 for exercise. And it doesn't have to be intense -- with weights, while it's always tempting to keep going up, I find I get the best results from light weights with lots of reps rather than heavy weights with fewer reps. And for exercise, 10,000 steps split into 4 separate walks is just as good as (if not better than) a single walking marathon every day, and is less likely to trigger hot flushes from overexertion.

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I understand your comment about using lighter weights, But there are situations where you need to use heavier weights.

I found that after seven years on Lupron , I could not stand up if on the floor. I had to lean into a chair heavily or on to a bed before I could get up. I’ve been using the leg press at the gym and I found that in the last few days that I can now easily get up from sitting in a chair. At first, I was only able to use 80 pounds in the leg press but I’ve been able to move up to 130, And now I can easily get up from a chair without holding onto anything. Before moving up to the higher weight, I could not do that. I probably don’t need to go any heavier, Getting my legs stronger has really helped. I can also now stand, Without help, After being on the floor.

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Profile picture for jeff Marchi @jeffmarc

A doctor at one of the conferences I attended recently said that he reduced the fatigue by increasing the prednisone from 5 mg to 7 1/2 mg. I know someone else that increased it to 10 mg and it worked for them. Ask your doctor.

Getting a lot of exercise is supposed to help in reducing the fatigue as well. Weight training and walking daily can really help, and they also offset the deterioration of your muscles that occurs when you’re on Zytiga and Lupron.

Jump to this post

+1 for exercise. And it doesn't have to be intense -- with weights, while it's always tempting to keep going up, I find I get the best results from light weights with lots of reps rather than heavy weights with fewer reps. And for exercise, 10,000 steps split into 4 separate walks is just as good as (if not better than) a single walking marathon every day, and is less likely to trigger hot flushes from overexertion.

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Profile picture for jwoy @jwoy

My husband had his first Lupron injection on Oct 15th. Started Zytiga a week later. No side effects at all until 3 weeks in. Then bam, soaking night sweats and big time fatigue. Care team started him on 100 mg Gabapentin to help with night sweats. Very helpful. Maybe a couple since starting that, but not nearly as bad. But, fatigue is still an issue, plus he started radiation 11/25, for 20 days.

Jump to this post

A doctor at one of the conferences I attended recently said that he reduced the fatigue by increasing the prednisone from 5 mg to 7 1/2 mg. I know someone else that increased it to 10 mg and it worked for them. Ask your doctor.

Getting a lot of exercise is supposed to help in reducing the fatigue as well. Weight training and walking daily can really help, and they also offset the deterioration of your muscles that occurs when you’re on Zytiga and Lupron.

REPLY
Profile picture for jwoy @jwoy

My husband had his first Lupron injection on Oct 15th. Started Zytiga a week later. No side effects at all until 3 weeks in. Then bam, soaking night sweats and big time fatigue. Care team started him on 100 mg Gabapentin to help with night sweats. Very helpful. Maybe a couple since starting that, but not nearly as bad. But, fatigue is still an issue, plus he started radiation 11/25, for 20 days.

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A fan in the bedroom with a remote control is a game-changer for hot flushes at night. You can get a good floor fan on a stand for well under $100, and he can use the remote to turn it on and off as needed without getting out of bed.

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My husband had his first Lupron injection on Oct 15th. Started Zytiga a week later. No side effects at all until 3 weeks in. Then bam, soaking night sweats and big time fatigue. Care team started him on 100 mg Gabapentin to help with night sweats. Very helpful. Maybe a couple since starting that, but not nearly as bad. But, fatigue is still an issue, plus he started radiation 11/25, for 20 days.

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I am on active surveillance after having had 4 Lupron D shots over a 12 month period. The last one was May 13 and it took until November 13 before the hot flashes came to an end! I did not have night time ones, thankfully. My testosterone level is 10, but I am already more energized. I can only hope and pray that I can maintain some stability. Time will tell.

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Some people don’t get severe hot flashes other people get a lot of fatigue. I would get 10 or more hot flushes a day, the first year On Lupron. Each hot flash would be preceded by a wave of fatigue. Most of the hot flashes would cause me to start sweating heavily sweat dripping down my head into my eyes. This is what some people have to face. My upper body would turn red.

One thing I did to try and Reduce the hot flash was drink a 16 ounce glass of ice cold water, Very quickly, It helped a little. I carried a battery Powered fan with me to try to cool off.

After A year I had a depo-Provera shot, Which almost completely stopped the hot flashes until I started taking Zytiga.

Never really noticed much fatigue, hot flashes, brain fog, muscle deterioration were the big issues.

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Fatigue is the biggest thing for me. The hot flashes are an inconvenience (I bought a neck cooling fan). I'll put up with both to be here.

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