Has this happened to you? BMD declines with both Prolia and Evenity

Do you take Vitamin K2 as well? It helps get the calcium in the bones. My dr said vitamin D3 gets the calcium out of your blood stream and K2 into your bones.

I have, but plan to do so more consistently. It's one of the variables that I can do something about.

I'm mainly curious to know if anyone else has ever experienced a decline -- especially two in a row with two different medications.

@brandysmom, I'm sorry to hear that the meds didn't work out as expected for you. I'd say for your recent dexa, a bmd decline of 2% may not be significant since this magnitude of change could stem from measurement errors. But still, your bmd didn't get improvements from evenity treatment.. Could the reason for evenity's "failure" be due to prolia's rebound effects?

Did your doctor offer any explanations for the outcome of either prolia or evenity? I'm curious about what your next follow-up drug will be.

I've seen two doctors: the first when the Prolia resulted in a BMD decline; the second now with the decline after taking Evenity. Neither doctor had an explanation, except to say it sometimes happens. I would love to connect with anyone else to whom this has also happened.

This has not happened to me, exactly. I was on alendronate for 3.5 years with no improvement, and am now trying Forteo. Sometimes certain meds just don't work for some people, but I don't know how common it is for two different meds to not work. Have you had tests to rule out secondary causes of osteoporosis such as hyperthyroidism,,hyperparathyroidism, celiac disease and Cushing's syndrome? Osteo meds won't help if you do have an underlying, untreated cause.

I'm so sorry about your experience.

My bone density improved and moved from osteoporosis to osteopenia without drugs.

Whether or not we take drugs for bone health, there is a lot we can do to help ourselves through diet, supplements, and exercise.

I second the comment to ask for testing. I advocated for myself and saw an endocrinologist who monitored me as I stopped taking thyroid hormones. I read that regardless of if the hormones make the thyroid hyperactive, the pill form extracts calcium from bones.

That's very interesting. I just saw a Naturopathic doctor who advised the same thing. When I stopped my thyroid medication for a week due to unavailability, I literally tanked in energy. Having my blood work done tomorrow to test my thyroid, but wondering what you did in alternative. You would think Endocrinologists would know this. I've been to two and neither mentioned it.

Yes, you would. 🙁

General practitioners and an endocrinologist missed how my old-school prescription issued 50 years ago was unecessary and harmful.

I uncovered it in my own research and find Google Scholar invaluable. Unfortunately, I've found many physicians' knowledge has not been current on an array of subjects, and it has been unusual for me to find one open to new information from a patient.

In my case,
even an endocrinologist suggested a medication withdrawal schedule that did not comply with standards.

As I recall, I advocated to reduce the hormones by a slight anount every few months. The doctor followed each reduction with a thyroid panel.

I believe I found the every few months time-line recommendation from the Society of Endocrinology. Although, I've read that it takes 4-6 weeks for thyroid hormone medication to exit the system.

I wish you the best!