1. < Digestive Health

HAS ANYONE TAKEN MOTEGRITY FOR GASTROPARESIS - AND IF SO DID IT WORK?

Posted by denisef @denisef, Jun 4, 2023

I have gastroparesis which was diagnosed on a gastric emptying study. My GI doc started me on Motegrity. It is primarily used for constipation but is apparently used "off label" for gastroparesis - it is a prokinetic and is supposed to stimulate the stomach to contract as well as the colon. i was started on 1/4 of dose and am titrating up. right now i am on 3/4 dose - and so far zeroooooooooo difference. Just wondering if anyone has had any success (or not) with this medication for gastroparesis.

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catmomma | @catmomma | Mar 17 8:14am

Hi,

It appears it's been some time since you posted-not sure how your'e doing. I have been on it for a short time, and am on 2mg. So far, the results are inconsistent, which isn't great-I see GI in Rochester for consults and I am hoping for a better report to give them at my appointment in May. But it's been a short time-only a couple weeks-it's also very expensive and that is hard for me, the insurance coverage is limited as it's non-formulary. And the manufacturer's coupon isn't available at the moment, their system for it was hacked and has been down for several weeks and there's no idea when it will be back up and running-regardless it may be back to the drawing board. Which stinks as I am running out of options.

Best to you!

REPLY
2 replies
cmaiwurm | @cmaiwurm | Mar 18 8:54am
In reply to @catmomma "Hi, It appears it's been some time since you posted-not sure how your'e doing. I have..." + (show)
@catmomma

Hi,

It appears it's been some time since you posted-not sure how your'e doing. I have been on it for a short time, and am on 2mg. So far, the results are inconsistent, which isn't great-I see GI in Rochester for consults and I am hoping for a better report to give them at my appointment in May. But it's been a short time-only a couple weeks-it's also very expensive and that is hard for me, the insurance coverage is limited as it's non-formulary. And the manufacturer's coupon isn't available at the moment, their system for it was hacked and has been down for several weeks and there's no idea when it will be back up and running-regardless it may be back to the drawing board. Which stinks as I am running out of options.

Best to you!

Jump to this post

Hello. My Mayo GI specialist gave me a written Rx for Motegrity and I sent off to a Canadian Pharmacy. I got a 84 day supply of 1mg for $251 and sent that off to my provider for potential reimbursement. UHC was paying 50% of $550 because of it being non formulary. Even if I don’t get reimbursed I am better off. There is only 1 manufacturer of prucalopride in the US with FDA approval - but there are 4-5 worldwide.

REPLY
cmaiwurm | @cmaiwurm | Mar 18 8:59am
In reply to @catmomma "Hi, It appears it's been some time since you posted-not sure how your'e doing. I have..." + (show)
@catmomma

Hi,

It appears it's been some time since you posted-not sure how your'e doing. I have been on it for a short time, and am on 2mg. So far, the results are inconsistent, which isn't great-I see GI in Rochester for consults and I am hoping for a better report to give them at my appointment in May. But it's been a short time-only a couple weeks-it's also very expensive and that is hard for me, the insurance coverage is limited as it's non-formulary. And the manufacturer's coupon isn't available at the moment, their system for it was hacked and has been down for several weeks and there's no idea when it will be back up and running-regardless it may be back to the drawing board. Which stinks as I am running out of options.

Best to you!

Jump to this post

I’ve been on it just 5-6 weeks. I’m 85% sure it is helping but I know that pyridostigmine didn’t work after taking that for a year. Chronic Pseudo Obstruction - cousin to gastroparesis.

REPLY
1 reply
catmomma | @catmomma | Mar 18 9:30am
In reply to @cmaiwurm "I’ve been on it just 5-6 weeks. I’m 85% sure it is helping but I know..." + (show)
@cmaiwurm

I’ve been on it just 5-6 weeks. I’m 85% sure it is helping but I know that pyridostigmine didn’t work after taking that for a year. Chronic Pseudo Obstruction - cousin to gastroparesis.

Jump to this post

I am considering the pyridostigamine as the insurance coverage is better for that-my copay is huge for the motegrity and though it's tax deductible, I just can't afford it.

I have gastroparesis and intestinal failure-managed symptomatically and with diet-though I have been on a j-tube and have also had TPN, I got off the TPN and signed a DNR order. The gastroparesis is complications form surgery. I've had most of the treatments and Reglan isn't an option as I take meds for bipolar disorder and they don't play well with one another-and I have had issues with tarditive dyskenesia with certain meds-and Reglan is famous for doing it.

Nausea is difficult to treat-so much I can't take and everything prolongs the QT interval-mine is getting to be about 350, too much higher and they will need to change my bipolar meds. Most of the nausea and GI meds prolong the QT interval. I am going to ask GI (Rochester) if the botox injections would be an option for me.

To make matters even worse, I have severe, chronic (intractable) pain. Anything that helps the pain makes the GI issues worse (nausea and motility). It stinks.

Thanks for reading-letting me vent.

REPLY
1 reply
cmaiwurm | @cmaiwurm | Mar 18 10:38am
In reply to @catmomma "I am considering the pyridostigamine as the insurance coverage is better for that-my copay is huge..." + (show)
@catmomma

I am considering the pyridostigamine as the insurance coverage is better for that-my copay is huge for the motegrity and though it's tax deductible, I just can't afford it.

I have gastroparesis and intestinal failure-managed symptomatically and with diet-though I have been on a j-tube and have also had TPN, I got off the TPN and signed a DNR order. The gastroparesis is complications form surgery. I've had most of the treatments and Reglan isn't an option as I take meds for bipolar disorder and they don't play well with one another-and I have had issues with tarditive dyskenesia with certain meds-and Reglan is famous for doing it.

Nausea is difficult to treat-so much I can't take and everything prolongs the QT interval-mine is getting to be about 350, too much higher and they will need to change my bipolar meds. Most of the nausea and GI meds prolong the QT interval. I am going to ask GI (Rochester) if the botox injections would be an option for me.

To make matters even worse, I have severe, chronic (intractable) pain. Anything that helps the pain makes the GI issues worse (nausea and motility). It stinks.

Thanks for reading-letting me vent.

Jump to this post

Wow, your plate is full, so sorry to hear about all of this.....

REPLY
crazykbl | @crazykbl | Mar 19 9:07am

Hey I use no tegrity for constipation but they also gave it to me for gastroparesis I didn't think it was helping for gastroparesis but I needed to stop taking it cuz it was giving me bad side effects I wasn't really helping when my constipation yes I did use it for gastroparesis. When I did use that I can eat more foods and I have so many side effects with the gastroparesis I didn't get vomiting 🤮 nauseated

REPLY
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