Has anyone taken Lynparza?

Hi @katgob, your experiences are helpful. How did you find Mayo Clinic Connect?

I am new here; I have been on a different side for a while. Simply, I ended up with Pancytopenia after 13 rounds of chemo and it continued with a version of the Olaparib pill that i was told was a cousin of Lynparza. This was December of 2021. In Feb i had surgery. I must add I was diagnosed with BRCA2+ in August of 2021. Come June of 2022, I was on Lynparza for 1 year. I was only stage 2, but I was Brca2 and Her2+. Er+/Pr-. My MO doctor felt this was a good choice. 200mg am and pm. 1/3 less than the 29 day pill i had in ecember. All in all, I was on Herceptin/Perjeta infusions for 18 rounds during this time. After each end side effects lessened. Joint aches, and neuropathy. Lynparza is a chemo pill, but no more hair loss. In all, my white cells remain low and platelets too. One great thing, the metal taste is gone.

@elizabethboie - thank you for your response - what was your dx and what was your dosage? As mentioned I'm TNBC BRCA 2+ and have completed my chemo, surgery and radiation.

I was on Lynparza for three years. I did not have many side effects.

@2opinion - how are you doing on Lynparza? I know you started in April and its been a couple months. I'm still trying to get everything in place so I can start on the medicine. I saw you dx - mine is different - I'm TNBC & BRCA2+. How long will you take this medicine?

I'd be interested in your side effects and what is your dosage. Mine will be 100mg 2 tablets/twice a day (so total 400 mg/day).

Brca 2 genetic gene.

No I do not.

My first week on it was ok but since then I feel like I have the worse flue ever. My bones hurt, not happy

Do you know what the lowest dose is?

Just spoke with Onco and we're starting the process to get insurance approval and payment assistance with Lynparza - Onco said probably be on it for only 1 year. Her thought is start at lowest dosage then work our way up in dosage as we see my tolerance. She believes that if you start at the max dosage and user has bad reaction - they may stop taking rather than reducing dosage. She prefers to start low ensure tolerance is good then increase from there. Thank goodness it's only for one year. As soon as process is complete and I know how I tolerate - I'll update, but that may be a month from now.