Has anyone suffer serious jaw bone issues resulting from taking Xgeva.

wden: Tell us more - did you have the infusion or experience issues?
My endocrinologist discussed this Tx for me. Since I was undergoing dental work (tooth extraction), we've delayed starting. I have a friend who had it with no problems.

How are you being treated for this? Osteonecrosis is very difficult to treat once it starts. Usually hyperbaric oxygen is used.

Before starting infusion had to have a tooth extraction in Jan 2025. 1st infusion in February. After 5 infusions had what at first thought to be a canker sore but worsened within a week. Oral surgeon examined. Thinks a result from Xgeva infusions ~ osteocronosis. Biopsy next week to verify then treatment. A common side effect for Prostate metastasis in the bones with these type of treatments.

Waiting on biopsy results to determine treatment plan.

I've been on Xgeva about one year and, so far, have had no complications. My oncologist opted for treatments once every 3 months, rather than monthly. His thousands of patients have responded about the same as other documented monthly treatments without as much risk. This is my personal experience having stage 4 metastatic prostate cancer for a decade, a radical orchiectomy and the full range of drugs and targeted beam radiation, including Pluvicto.
Good luck, and do your homework to make the best decisions.

It would have been better if they had waited for more complete healing before starting the infusions.
Some extractions can take months for the socket to heal over, and complete bone fill can take over a year. Of course, your life depended on the infusions so waiting for complete healing was not possible…but another month would have probably made a difference…best of luck!
Phil

geva vs Prolia. How do they compare?

Drugs.com
https://www.drugs.com › Medical Answers
Apr 3, 2024 — Xgeva and Prolia are both brand names for the generic drug denosumab. Both are injectable preparations, both are made by Amgen, and both have similar side ..

OHIP in Canada no longer pays for Xgeva