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Has anyone looked into the miR Sentinel Prostate Cancer Test?
Has anyone tried or looked into the miR Sentinel PCa test?
It seems to hold great promise as an alternative to a traditional follow-up TRUS biopsy for those on active surveillance, along with other potential PCa screening and after treatment uses.
https://www.urologytimes.com/view/novel-urine-based-liquid-biopsy-launched-in-us-prostate-cancer-marketDr. Klotz (one of the pioneers in AS) gave an interesting 10 minute presentation of this test in 2020. The Sentinel test shows a 93% sensitivity in identifying clinically significant cancer and a 96% negative predictive value for non-significant cases and classifies PCa into none present, low-risk, intermediate-risk, or high-risk disease.
https://grandroundsinurology.com/the-mir-scientific-sentinel-assay/A large clinical trial has been ongoing for 4 years and is scheduled to be complete at the end of December 2024.
https://clinicaltrials.gov/study/NCT04100811The miR Sentinel PCa test costs are apparently comparable to TRUS biopsy and/or mpMRI, however, I understand Medicare does not currently cover its cost...maybe that will change once the clinical trial results are published.
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I heard a lecture from Dr. Klotz from September, 2024. It was a PCRI conference he was presenting at. He stated at the beginning of his lecture that miR Sentinel had declared bankruptcy and "that not too much was going to happen going forward in regards to that test". His lecture begins at about 1:37:00.
Thanks for finding that out, that's certainly disappointing!
The initial results were almost too good to be true...maybe they were...who knows why they had to file Chapter 11????
I wonder what will become of their technology and the clinical trial????