Gut microbiome dysbiosis, and duration of adjustment symptoms

I would be very interested, and grateful, to hear from anybody who has experienced prolonged “adjustment symptoms” after taking a probiotic, who then, subsequently, experienced a significant, successful and permanent improvement in their IBS symptoms, or know of any bona fide clinical
studies relating to the duration of adjustment symptoms. The manufacturers of the myriad number of probiotics, regularly vaunt reviews from patients who claim significant changes to their IBS symptoms with their product without, apparently, citing clinical validation- , or long term post-marketing studies.

My IBS-C developed 8 years ago after a severe viral illness, against a background of very stressful employment, and an adverse lifestyle, both factors of which were the undoubted cause of significant gut microbiome dysbiosis. Colonoscopy revealed IBS confined to the sigmoid colon not reversed with IV Hyoscine, and was labelled as, severe, atypical IBS-C

I have suffered intractable symptoms of IBS-C for eight years, without any significant improvement from the array of allopathic treatments, including Amitriptyline and SSRI’s, and dietary manipulation, but I did experience an improvement in constipation with Alflorex, but not bloating or pain.
I started, some 18 weeks ago, a relatively new, novel probiotic, marketed in the UK as Ferrocalm. It’s a single strain of Streptococcus Thermophilus which, purportedly, has been engineered to utilise iron released into the gut during periods of stress when IBS relapses, which standard probiotics are unable to do, and, thus, compete with pathogenic bacteria. The suggestion is that explains why some IBS sufferers do not respond to those standard probiotics.
My adjustment symptoms, including those of the Jarisch-Herheimar type, began on day 1 , and still persist to date, without any features to suggest IBD or a GI neoplasm.

I have spoken to the clinical lead of the company which manufactures this product, but she was unable to furnish any post-marketing studies beyond 8 weeks.

I understand that the correction process can take up to two years to correct, depending on the severity of the dysbiosis, and other factors.

I remain quite sanguine that my IBS will improve significantly once the adjustment has taken place. Moreover, that I have been led to believe that microbiological analysis of stool samples are not helpful in determining the correction process.

Regards

Michael