If you took GLP-1s for weight loss, did it help your Neuropathy?

I’m sorry to hear that the Mounjaro injection makes you feel crappy. I have not had this reaction and I wonder if others can comment on this. With my weight loss, my feet really don’t bother me much during the day but I still have some pins and needles at night.

@oldbubba I have been on Mounjaro since mid June now. Lost about 25 lbs. My blood pressure has also normalized. I can say that for 12-48 hours after each injection, I feel pretty crappy. Some of my early PN symptoms that had subsided, have returned to some extent. I feel normal after a day or two.

Two years ago I went to Iceland on the way to Scotland. My son and daughter-in-law were with me. We went to the Blue Lagoon which is the cooling pond for the geothermal power plant. The water is around 100 degrees F. It is a great way to relax especially after a five hour flight. I had a blister on my right big toe that opened up when I shower after the soak. (you shower before--to get clean--and after--to get rid of the salts from the lagoon. I got an infection and eventually lost the distal first bone on my right big toe.

I have been having foot cramps in my right foot ever since the surgery. I was told to wear compression socks. Within days, my foot cramps stopped. I am also diabetic and have PN that goes half way up my lower legs. The compression socks have also relieved some of the pain of PN.

I have gone through Trulicity, Ozempic, and now starting on Mounjaro. I have lost over 66 pounds (30 Kgrams)

I have taken Mounjaro (Tirzepitide) for 3 years for reduction in blood glucose. I'm type 2 diabetic. It is effective for that condition. Prior to that I had taken Trulicity for 2 years which had become less effective. As far as I can tell neither has had any effect on my neuropathy. However, my daughter also takes Tirzepitide it for weight loss and it has reduced joint pain associated with ulcerative colitis.

@jpj1952
My issue is primarily balance. What was your experience?

Thanks.

GLP-1 for 18 months, no impact on my Neuropathy.

Glp-1 for 2 years, not diabetic
It did not help my CIAP, chronic idiopathic axonal neuropathy

Nope ..not for me... I'm not a diabetic
Mine most likely came from either Covid or the alcohol during covid..
Now alcohol and sugar/gluclose starts it up..

I've been taking the GLP tirzepatide for 18 months. It has helped with osteoarthritis stiffness and pain--about a 30% reduction in those symptoms. I went off tirzepatide at one point due to severe constipation, and the stiffness and pain came back in full force. I went back on it specifically for pain relief, but this time with a better plan for preventing constipation, and the pain was again reduced.
But tirzepatide didn't do anything for my severe neuropathy from damaged spinal nerves from severe scoliosis. My spine is crazily twisted and there's no space for the nerves to my limbs.
However...the chronic pain team at Kaiser put me on memantine, an old Alzheimer's drug, and it has been absolutely wonderful for neuropathy--with zero side effects! You have to ramp up the dose over a month so I wasn't sure at first, but by the 4th and 5th week there was no doubt about it--the neuropathy in my legs and arms has decreased by 80%. It's fantastic!
Sadly memantine doesn't work for everyone--in my chronic pain support group one other person got very good results but another person got no relief.