Gleason 7 (4+3) radiation, but ADT also? Over treatment?

It really is 15 years not 17. I never had metastasis in the first eight years, So I don’t think chemo would’ve been in the picture even if they knew I had BRCA2. Only one Metastasis on the spine (L4) so far. Waiting for the pin to drop!!!

People are SO different in how their bodies react to PC. I don’t know if it helps but mentally I have not really been concerned about my PC getting worse. I don’t really think about it, Even when waiting for the results of my monthly PSA tests. Does mental attitude make a difference??? Nahhhhh!!

Thanks for your comments and I will ask about the decipher score which has not been mentioned to me by my care team.
Happy New Year to you as well!

So perhaps the addition of ADT earlier might have made a difference? But I think you’ve pointed out that the BRCA2 problem might have even eclipsed ADT and caused the cancer to come back anyway.
I guess today you would have gotten the triplet therapy regimen - that’s ADT combo plus chemo?
Still amazing to me that you have beaten this thing back for 17 years and are still standing strong….Happy New Year, Jeff, and thank you once again for all your help, knowledge and support!
Phil

Thanks Jeff ,
I am a Prostate Cancer Advocate . I am pretty much up to date on the International Current & Emerging Treatments , many of which have been slow on the uptake by the FDA .
I plan to avoid ADT at all costs if possible . Sometimes the cure is worse than the disease . I have personal experience watching both my brothers-in-law . They were dignosed at stage 4 -- Both passed inside 2 years .
Ages 89 AND 86 . Both had listened to the BS theory : " You will die with cancer - Not from it" and had stopped getting their PSA .

I had salvage radiation and no ADT. Took 2.5 years to come back, and I have BRCA2. Then I started ADT.

He is 79

Side effects were hot flashes from being on ADT for six months, It lasted for a year after ADT was stopped. Use Orgovyx for the ADT drug and your testosterone will recover quickly. Ask your doctor if he thinks it’s appropriate for you.

He had problems peeing so he went on Flomax and that resolved it. He had that problem for about a year, on and off.

Your monotherapy option sounds just right, But I am not a doctor. I have not reviewed your medical scans and documentation so I don’t know exactly what’s going on. If it’s truly isolated to the prostate, then SBRT works great for most people. At your age you have many more years before prostate cancer becomes an issue, there are so many treatments.

Your timing for getting off ADT sounds just right. Just make sure to get those PSA tests no less than every three months.

I went from 4 abiraterone pills to 3 to try and improved brain fog issues. In 18 days, my PSA went from .2 to 1. I went right back on four pills. Just something to think about, Mine was never below .09 and you are able to get to .03, yours is essentially undetectable.

You don’t mention a decipher score. Is there any chance you could get one, That can tell you how aggressive your cancer is, more info than the Gleason score.

Have a great New Year.

My prayer everyday is to get off of Orgovyx plus Abberaterone (plus Prednisone) to regain testosterone and quality of life.
I’m 68 with Gleason 8, stage 3 advanced,and baseline PSA of 7.0
I’m 9 months into ADT and 43 radiation treatments this past summer.
I’ve taken to heart from the start of ADT the crucially important need for daily resistance training and it has made a major difference for me.
Last PSA score in Nov was 0.03 so I’m hoping to string together maybe 3 more of those or better scores (9 months) and get off ADT earlier than the prescribed 24 months.
Thanks in advance for any thoughts/comments

Jeff,
What age is your brother now ? What were his side effects ?
Thanks .
p.s. I am considering Monotherapy SBRT . I am coming 85 years young.

I actually read this article when I first knew I would need salvage radiation. I consulted with an RO who totally agreed with the article, telling me that any PSA less than .7 did not need ADT, only radiation.
I then consulted with Sloan and they said I DID need ADT, which had been my feeling, in spite of the newer findings. I asked my urologist what he thought and he said that although the newer findings supported the idea of no ADT, 6 months on Orgovyx in an otherwise healthy or medically supervised patient “couldn’t hurt”.
My feeling was that my Gleason 4+3 unfavorable just might be a bit more aggressive than “Intermediate” might imply and even though my surgical pathology was negative, it STILL recurred. So I wanted to hit it as hard as I could so hopefully I could end this problem once and for all🤞