1. < Osteoporosis & Bone Health

Forteo after breast cancer

Posted by sue417 @sue417, Jun 5 9:23am

Hi
Has anyone that has had breast cancer and treatment like chemo , radiation done forteo. I finished radiation apr 2024.
I am sort of stressed about having to start this medication for my osteopenia and my recent spinal fractures. I have read that a side effect of this if you go longer than twenty four months is bone cancer.

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mayblin | @mayblin | Jun 5 10:23am

No definitive increased risk of osteosarcoma has been confirmed during many years of post marketing surveillance, although limited data available for use beyond 2 years. The observed osteosarcoma incidence in lab rats was due to the high dose (3-60 times higher than what we are using) and length of treatment (rat’s lifetime). The bone biology of rat is also starkly different from that of human which means they are not perfect models for studying drugs like Forteo.

FDA does have warnings for people who had prior radiation therapy. I read that the area of bone that was involved and the extend of radiation (dose?) matter. This needs to be carefully evaluated by your radiation oncologist and endocrinologist so that you could make a decision based on risk vs reward.

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sue417 | @sue417 | Jun 5 10:59am
In reply to @mayblin "No definitive increased risk of osteosarcoma has been confirmed during many years of post marketing surveillance,..." + (show)
@mayblin

No definitive increased risk of osteosarcoma has been confirmed during many years of post marketing surveillance, although limited data available for use beyond 2 years. The observed osteosarcoma incidence in lab rats was due to the high dose (3-60 times higher than what we are using) and length of treatment (rat’s lifetime). The bone biology of rat is also starkly different from that of human which means they are not perfect models for studying drugs like Forteo.

FDA does have warnings for people who had prior radiation therapy. I read that the area of bone that was involved and the extend of radiation (dose?) matter. This needs to be carefully evaluated by your radiation oncologist and endocrinologist so that you could make a decision based on risk vs reward.

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Hi
Thanks for the info. So I guess I better make a call to my radiologist. I will be surprised if he actually has info. I had rt breast radiation 10 days. 5 tumor specific and 5 whole breast. Dbl dose. I had dcis hormone positive her 2 neg stage 0. Microscopic break in the milk duct wall.

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mayblin | @mayblin | Jun 5 11:06am

Definitely a good idea. Endocrinologists who had encountered similar cases like yours would have great insights too.

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