Foot pain or neuropathy after zytiga chemo treatment side effects?

Posted by mwolff @mwolff, Feb 27 10:35am

I am coming off of 2 years for treatment for prostate cancer. I had High dose rate (HDR) brachytherapy to start with then 25 radiation treatments. Along with Luprin and zytiga chemo. I was cleared of cancer August 2025 and finished my luprin and zytiga Nov 2025.
Over the last couple months my body been aching i get tingling trough my body along with severe pain in my feet. As well as being weak in my arms.

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jeff Marchi | @jeffmarc | Feb 27 11:58am

From an AI search

Stopping Androgen Deprivation Therapy (ADT) and Zytiga (abiraterone acetate), especially if done abruptly, can lead to withdrawal symptoms and a "shock" to the system as it readjusts to changing hormone levels. The symptoms you are experiencing—body aches, tingling, severe foot pain, and arm weakness—are likely related to a combination of adrenal insufficiency, acute hormonal shifts, and residual nerve/muscle damage from long-term treatment.

Not sure how you tapered prednisone, but it must be tapered off over a month or more or side effects can really last a long time.

Cause of Aches and Weakness: When prednisone is stopped, the adrenal glands may not immediately produce enough cortisol on their own, leading to adrenal insufficiency.
Symptoms: This condition commonly manifests as extreme fatigue, generalized weakness, muscle pain, joint pain, and nausea.

When you were on ADT/Zytiga, your body was in a "super-castrate" status, which, while fighting cancer, causes significant changes to joint and bone health.
PubMed Central (PMC) (.gov)

Aches and Pain: As your body begins to recover, or as hormone levels shift rapidly, you may experience increased muscle and joint pain, often referred to as musculoskeletal withdrawal symptoms

Do a search of AI for the following and you can get some information on Solutions.

“after stopping ADT and Zytiga what causes the following problems body aching i get tingling through my body along with severe pain in my feet. As well as being weak in my arms.”

bonanzaman | @bonanzaman | Feb 28 7:45am

Hi, I've been having pain and numbness in my toes and feet and what I found that seems to work is vitamin B-Complex and Taurine. I do them in the morning and they seem to help me.
It can be pretty annoying trying to sleep when the feet hurt/burn.
Good luck!

Dave