Follow Up Treatment for Evenity Injections

Posted by lros @lros, Jul 27 10:32am

Has anybody tried Evista or any other SERM as their follow-up treatment for Evenity? I just received the 7th Evenity injection, and I need to decide my next step. For most people, an antiresorptive medication is recommended as a follow up treatment, and SERMS are antiresorptive. However, I cannot find any studies that support using SERMS instead of Prolia or Bisphosphonates. Most doctors recommend going with the stronger drugs. However, I would prefer using a drug that has less side effects.

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dstovall1800 | @dstovall1800 | Jul 27 11:10am

Did injections they did not work for me

mayblin | @mayblin | Jul 27 11:23am

I'd think if you're in a low bone turnover state - like in a treatment-naive situation, based on CTX and P1NP - it may work since it's a milder antiresorptive.

lros | @lros | Jul 27 5:09pm

In reply to @dstovall1800 "Did injections they did not work for me" + (show)

I don't know yet. I have a bone density scan scheduled in a couple of months.

lros | @lros | Jul 27 5:44pm

In reply to @mayblin "I'd think if you're in a low bone turnover state - like in a treatment-naive situation,..." + (show)

I don't believe I was treatment naive when I started the Evenity injections. I started treatment with hormone replacement therapy in 2010 and did this for a few years. Then I switched to Evista which I took for about 5 years. This may be considered treatment-naive, but I'm not sure. My last CTX in June of 2025 showed I was in the normal range. I had a BALP (bone specific alkaline phosphatase) instead of the P1NP. It was also in the normal range. Do you base your opinion on a study? My feeling is that Evista would work for me. I think the main objection by the medical community is that Evista works with the spine and not the rest of the skeleton. However, this could work for me. My T Score in my spine is very low, but my left hip T Score in 2023 was -1.6. Because of this, I would be willing to take a chance on the Evista because of the way it works and less side effects. If you know of any studies done on Evista as a follow up to Evenity, please let me know.

mayblin | @mayblin | Jul 29 7:20pm

In reply to @lros "I don't believe I was treatment naive when I started the Evenity injections. I started treatment..." + (show)

I see. If you’ve used Raloxifene before, that could give you a bit of background information - especially if you had CTX levels checked while on it. That would show how well it was working to suppress bone resorption for you. I’ve come across studies on Raloxifene used after drugs like Forteo, or Prolia (not strong enough for rebound after prolia cessation) but I haven’t come across using it after Evenity in clinical studies.

pyates | @pyates | Jul 29 9:09pm

In reply to @dstovall1800 "Did injections they did not work for me" + (show)

Does your doctor know why the injections didn't work? Did he/she work out an alternative bone regeneration plan, using anabolics and/or bisphosphanates?

I ask only because I'll be starting injections pretty soon. I'm wondering what to expect; I didn't realize that some people don't get a therapeutic effect from these meds.

dstovall1800 | @dstovall1800 | Jul 30 3:28am

In reply to @pyates "Does your doctor know why the injections didn't work? Did he/she work out an alternative bone..." + (show)

I did this and it didn’t work.0

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bruceandruth1970 | @bruceandruth1970 | Jul 30 10:55am

In reply to @dstovall1800 "I did this and it didn’t work.0 Sent from Yahoo Mail for iPhone" + (show)

Did you get all 12 injections of Evenity?

lros | @lros | Jul 31 4:25pm

In reply to @mayblin "I see. If you’ve used Raloxifene before, that could give you a bit of background information..." + (show)

Good point about the CTX levels. They were in the normal range while I was taking raloxifene.

lros | @lros | Jul 31 4:44pm

In reply to @mayblin "I see. If you’ve used Raloxifene before, that could give you a bit of background information..." + (show)

Three CTX tests were in the 500s ((Normal Range: 104 to 1008 pg/mL). One was 630 and one was 886 pg/mL. All while taking raloxifene. Same here on the studies - only done for Forteo or Prolia and not Evenity.