Follow Up Treatment for Evenity Injections

Posted by lros @lros, 1 day ago

Has anybody tried Evista or any other SERM as their follow-up treatment for Evenity? I just received the 7th Evenity injection, and I need to decide my next step. For most people, an antiresorptive medication is recommended as a follow up treatment, and SERMS are antiresorptive. However, I cannot find any studies that support using SERMS instead of Prolia or Bisphosphonates. Most doctors recommend going with the stronger drugs. However, I would prefer using a drug that has less side effects.

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Did injections they did not work for me

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I'd think if you're in a low bone turnover state - like in a treatment-naive situation, based on CTX and P1NP - it may work since it's a milder antiresorptive.

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@dstovall1800

Did injections they did not work for me

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I don't know yet. I have a bone density scan scheduled in a couple of months.

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@mayblin

I'd think if you're in a low bone turnover state - like in a treatment-naive situation, based on CTX and P1NP - it may work since it's a milder antiresorptive.

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I don't believe I was treatment naive when I started the Evenity injections. I started treatment with hormone replacement therapy in 2010 and did this for a few years. Then I switched to Evista which I took for about 5 years. This may be considered treatment-naive, but I'm not sure. My last CTX in June of 2025 showed I was in the normal range. I had a BALP (bone specific alkaline phosphatase) instead of the P1NP. It was also in the normal range. Do you base your opinion on a study? My feeling is that Evista would work for me. I think the main objection by the medical community is that Evista works with the spine and not the rest of the skeleton. However, this could work for me. My T Score in my spine is very low, but my left hip T Score in 2023 was -1.6. Because of this, I would be willing to take a chance on the Evista because of the way it works and less side effects. If you know of any studies done on Evista as a follow up to Evenity, please let me know.

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