What were your first signs of endometrial cancer?

Endo cancer stage 3. They didn't say exactly, except that those individuals with it seem to have better outcomes. I've tried to gain insight about it, why I was seeking more info on it to know how to approach it best, cause I haven't started treatment yet, they want to start this next week. Really need guidance

@tdfraze Hello again. I just welcomed you to Mayo Clinic Connect in a different discussion (What Kind of Radiation Therapy Did you Have?).

Memorial Sloan Cancer Center: POLE Mutation Gene:

-- https://www.mskcc.org/cancer-care/patient-education/about-mutations-pole-gene

What did your doctor say about how the POLE Mutation affected you? Were you diagnosed with endometrial cancer? Ovarian cancer?

9 years post ovarian cancer and total hysterectomy/oophorectomy, and not having had a UTI since childhood, a slowly increasing pressure sensation on one side of my bladder was getting intense to the point it felt like a burning sensation on the OUTSIDE of the bladder when voiding. No bleeding. A little fullness in the lower part of the belly. Was starting to feel that starving, then sudden fullness after only a few bites, too. Had just finished signing papers to end a 33-year marriage and thought I may be getting an ulcer due to the circumstances. Went to see the GP who had been following me for almost 30 years, and he said it just didn't sound "normal" for me. Did the CA-125, the CT, the MRI, the ultrasound, the vag. ultrasound and when the results came back, they said a kidney was being pinched off by something which led to the surgery where they found cancer to be obstructing the ureter and stuck to the bladder and lining the lower right quadrant of my intestinal cavity. Needless to say, as with the ovarian cancer surgery 9 years previously, the laparoscopic surgery they had promised ended up in a full xyphoid to pubis incision (again!), along with waking up for the 2nd time in my life being told what they initially thought was benign was actually cancer. Great surgeon! 5 weeks of radiation and it's a blessing to be here!

My Dr orders CA125's every 3 months and an MRI yearly as standard and additional if any symptoms warrant.
I am 3 years out since diagnosis (Feb 4th 2022).
What is everyone else's experience with surveillance? What do your doctors order to ensure a recurrence is caught in a timely manner?

2017, so its been 8 years now. The insurance I have through my employer is no longer covering the ongoing yearly testing the oncologist has recommended, so going forward it will be a tough decision to be re-tested yearly. It is unfortunate we have to make decisions like this, particularly when one works for a top medical facility in the world, one would think it should/could be covered as preventative care.

2017, so its been 8 years now. The insurance I have through my employer is no longer covering the ongoing yearly testing the oncologist has recommended, so going forward it will be a tough decision to be re-tested yearly. It is unfortunate we have to make decisions like this, particularly when one works for a top medical facility in the world, one would think it should/could be covered as preventative care.

@jane Thank you for sharing your experience. It's so good that you have a GP who has been your doctor so many years and took you seriously. I agree. You have a wonderful GP, surgeon, and radiation oncology team. When did this more recent cancer that was obstructing your ureter occur?