First BCG treatment: What to expect?

Posted by dswanson @buena, Apr 1, 2025

Yesterday marked my first adventure with BCG. The treatment went well. I was surprised by the small amount of BCG that was administered. I expected to experience a full bladder but, in reality, had no uncomfortable fullness. I thought I would be asked to lay in various positions to allow the BCG to reach my entire bladder. That wasn't necessary. I remained on my back for 60 minutes with a pillow, a warm blanket and a tv remote control. (I remained because I am incontinent and the BCG would have leaked out had I been released after administration of the medication.) Since my departure, have experienced burning sensations when urinating and a tiny amount of blood, but no other symptoms. Have been flushing twice, washing my hands and keeping my Depends in a separate bag for disposal. Otherwise, no special measures. Doing fine and grateful for the compassionate care and expertise available in Urology at Mayo Clinic Rochester. Also appreciate this helpful web site. Thanks Mayo.

Interested in more discussions like this? Go to the Bladder Cancer Support Group.

Profile picture for mucimom @mucimom

Are you being administered
TICE BCG or rBCG treatments?

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@mucimom, welcome.
Theracys and Tice are name brands of Bacillus Calmette-Guérin (BCG)

rBCG stands for Recombinant Bacillus Calmette-Guérin, which is a genetically modified version of the traditional Bacillus Calmette-Guérin (BCG) bacteria. It is available through expanded access programs to help address the BCG shortage.

Which type of BCG are you getting, @mucimom?

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Profile picture for jcarolyn @jcarolyn

I am getting BCG treatments right now and have had 5 so far. No pain, I just experience some urge incontinence on treatment day and a little fatigue day after. I also experienced very mild headaches day after treatment but just for the first two treatments. All in all, no complaints. Good luck!

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@jcarolyn, welcome. I hope things continue to go well for you with treatment. Have you finished BCG treatments now? How are you doing?

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Profile picture for carmen332 @carmen332

Just diagnosed with bladder cancer. Cysto showed all clean on inside, catscan showed all normal on outside. Biopsies showed carcinoma in two locations. Both were confined to interior no invasion of muscle wall. Doc prescribed immunotherapy with BCG solution injected directly into bladder. Series of 5 injections spaced weekly required.
Has anyone experienced this treatment? If so was treatment successful and were there any side effects? Thank you for any info you can provide

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@carmen332, getting a liquid drug directly into your bladder rather than giving it by mouth or putting it into your blood is called intravesical therapy. The drug is given through a tube (urinary catheter) that's been put into your bladder through your urethra.

There are 2 main types of medicines used in intravesical therapy:
- Immunotherapy
- Chemotherapy

Bacillus Calmette-Guerin (BCG) is the most common intravesical immunotherapy for treating early-stage bladder cancer.

There are many discussions where members share their experiences with BCG, like this one:
- First BCG treatment: What to expect? https://connect.mayoclinic.org/discussion/first-bcg-treatment-what-to-expect/

See all using the group search: https://connect.mayoclinic.org/group/bladder-cancer/

Have you had your first treatment yet? How are you doing?

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First, good to hear you are at Mayo, a first rate clinic which is important. I’m about to start my first maintenance series of BCGs after a successful initial series of 6 and a good report from my cystoscopy. My side effects have been minimal. Plus I do not have to stay lying down or rolling around. I’m told that’s old school procedure. I leave the clinic immediately after the procedure and drive home.

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Profile picture for carmen332 @carmen332

Thank you and may God Bless You. These treatments are tough.

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@carmen332 I do recommend being treated at a top notch cancer clinic. Top docs are what you want, to avoid misdiagnoses.

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Are you being administered
TICE BCG or rBCG treatments?

REPLY
Profile picture for carmen332 @carmen332

Just diagnosed with bladder cancer. Cysto showed all clean on inside, catscan showed all normal on outside. Biopsies showed carcinoma in two locations. Both were confined to interior no invasion of muscle wall. Doc prescribed immunotherapy with BCG solution injected directly into bladder. Series of 5 injections spaced weekly required.
Has anyone experienced this treatment? If so was treatment successful and were there any side effects? Thank you for any info you can provide

Jump to this post

Thank you and may God Bless You. These treatments are tough.

REPLY
Profile picture for carmen332 @carmen332

Just diagnosed with bladder cancer. Cysto showed all clean on inside, catscan showed all normal on outside. Biopsies showed carcinoma in two locations. Both were confined to interior no invasion of muscle wall. Doc prescribed immunotherapy with BCG solution injected directly into bladder. Series of 5 injections spaced weekly required.
Has anyone experienced this treatment? If so was treatment successful and were there any side effects? Thank you for any info you can provide

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I'm about to start along with Imfinzi a new medication that gives a %36 chance of working better with BCG there is a world wide shortage of the TB version so I'll be on BCGr a man made trial both are trials the FDA just released the Imfinzi it was working on people with small cell Lung cancer, until recently most who had small cell Cancer didn't have much luck , my brother had Bladder cancer so it is hereditary, he's now 9 months cancer free , we will be dealing with this the rest of our lives unfortunately, my late Uncle Hank had it for at least 20 years kept coming back, worse side effects ac wording to my brother is stinging when you pee, I couldn't pee because a tumor was blocking my Bladder neck good luck I'll pray for you 🙏

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Profile picture for carmen332 @carmen332

Just diagnosed with bladder cancer. Cysto showed all clean on inside, catscan showed all normal on outside. Biopsies showed carcinoma in two locations. Both were confined to interior no invasion of muscle wall. Doc prescribed immunotherapy with BCG solution injected directly into bladder. Series of 5 injections spaced weekly required.
Has anyone experienced this treatment? If so was treatment successful and were there any side effects? Thank you for any info you can provide

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Than you. That is what i am hoping for.

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Profile picture for carmen332 @carmen332

Just diagnosed with bladder cancer. Cysto showed all clean on inside, catscan showed all normal on outside. Biopsies showed carcinoma in two locations. Both were confined to interior no invasion of muscle wall. Doc prescribed immunotherapy with BCG solution injected directly into bladder. Series of 5 injections spaced weekly required.
Has anyone experienced this treatment? If so was treatment successful and were there any side effects? Thank you for any info you can provide

Jump to this post

I’ve had my first 6 and a clean cystoscopy after. For me there were virtually no side effects, but that varies widely among patients. Good luck!

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