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Exercise as Medicine: P.C.R.I. Q&A with Rob Newton
Rob Newton's most recent explanation of his research. I can't understand why most doctors pretend that exercise isn't something they should be prescribing for their patients as vigorously as they prescribe ADT. Rob has the data, and he has the energy to try to change this world.
At one point in the video, Rob gets emphatic: “Exercise is treated now as first-line therapy”. What he means is it should be treated as first line therapy, because at present, US oncologists pretend they don't see how exercise could be used as a first line treatment, if it was any good anyway.
Rob pauses. “Wow. It's first-line therapy because of the CHALLENGE study”.
The phase 3 CHALLENGE study https://www.asco.org/about-asco/press-center/news-releases/movement-medicine-structured-exercise-program-challenge result was that a group of patients that were prescribed a structured exercise program in one arm of the study had a 28% lower risk of recurrent or new cancers developing than patients in the control arm.
And the thing is, no one was telling the control arm patients not to exercise - in fact, they received health education materials that encouraged then to do so. I wonder how much of a benefit the structured exercise group would have compared to a typical group who were offered the standard no mention of exercise while they are slashed, burnt and drugged while being told they are getting the best treatment available.
I think about my radiation oncologist explaining to me that for less of a benefit than the CHALLENGE study demonstrated that structured exercise is, I should go on his prescribed ADT program for 2 years. When I brought up exercise and mentioned Rob, he politely ignored me.
Rob continued: “We now have a randomized controlled trial in a large number of patients that shows it has a direct causative effect in increasing survival.”
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"28% lower risk of recurrent or new cancers" - This is one finding, and an important one! It also found a 37% lower risk of death from any cause. Pretty good reason to start exercising!
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3 Reactions@smoore4 Gee, 37% lower risk of death from ANY cause?? That is one loaded statement right there!😂
Phil
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2 ReactionsThis is an older video, but does show that Exercise is a good tool in our toolkits for optimal health.
See: https://www.youtube.com/watch
The Challenge study mentions Stage II or III American Cancer Society defines: level IIA and IIB and III as: (sounds fairly advanced in level III, so any improvement would be worth the exercise I think. )
T3
The cancer has grown into the outermost layers of the colon or rectum but has not gone through them (T3). It has not reached nearby organs. It has not spread to nearby lymph nodes (N0) or to distant sites (M0).
IIB
T4a
The cancer has grown through the wall of the colon or rectum but has not grown into other nearby tissues or organs (T4a). It has not yet spread to nearby lymph nodes (N0) or to distant sites (M0).
III T1
The cancer has grown through the muscularis mucosa into the submucosa (T1). It has spread to 4 to 6 nearby lymph nodes (N2a). It has not spread to distant sites (M0).
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1 Reaction@heavyphil
I can't figure out how they do the math.
The study states that 80% of the structured exercise group did not experience recurrent or new cancer after five years, whereas only 74% of the control group made it cancer free to that point. Some math boffin interpreting the study turned this into the structured exercise group had a 28% lower risk of experiencing cancer.
And the study states that after 8 years, 90% of the structured exercise group were still alive, compared to 83% of the control group. Presumably the same math boffin feeding reporters turned this into the structured exercise group had a 37% lower risk of death from any cause.
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3 ReactionsStudy of one...
This seems intuitive, a blinding flash of the obvious. We generally understand that with regards to our overall health, activity makes things "better." It is interesting to see from the science point, how it impacts our survival with PCa.
Last year my gym, Lifetime Fitness, said I visited 272 times...
Each visit consisted of 45-60 minutes on the exercise bike, resistance training, 500-1000 meters swimming and hot and cold tub.
There were some 30+ days of outdoor bike riding, 25-50 miles...
Throw in vacations that often include hiking - Sedona, Rocky Mountain National Park, Aspen and Lake Tahoe.
My clinical history may portend the value of all that exercise. My radiologist and oncologist say they agree.
Since I do this on my own, there is no "science" behind it but based on the video and other articles on the subject, I am going with, it's a factor.
Interesting, in a discussion with my electro cardio physiologist who routinely sees me twice a year after my cardio ablation, she agrees that given my health history since 2010 - DVT, PE, AFib, PCa, TIAs, the active lifestyle may very well be a reason that I am here and still able to be active.
Kevin
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9 Reactions@climateguy
They do that kind "of math" in general, that is how they do estimations and that is why simple % comparison for us lay people is better for understanding results. That is why it is important to read a study in full and not just "conclusions". For example "25% better result" can actually be just 2% difference in overall survival in reality (I am talking about one other study that I read regarding adjuvant vs salvage results).
That to the side - exercise and nutrition have great effect on overall survival and well being in general and new recerch is done in the area of PC prevention as well as BCR prevention. UCSF is at the moment recruiting post treatment PC patients for study of BCR prevention - one cohort will be with patients who will follow nutrition guidelines and the other exercise protocols.
I do not think that with limited finding nowadays and with low research budget research centers like UCSF would conduct those kind of studies if there are "zero effects" expected. ; )
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3 Reactions@climateguy Yeah, sorry, I was being a bit facetious…death by any cause also includes auto accidents, falls from windows and rooftops, electrocutions, OD’s…
Don’t think we can exercise our way out of those!😂. Sorry for being a pain…
Phil
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2 Reactions@heavyphil
My wife hates to fly, she's concerned about the plane falling out of the sky, crash landings...
I tell her, "we are at greater risk driving to and from the airport than being on the darn plane...
As I say about growing, manage the things in your wheelhouse:
Diet
Exercise
Managing stress
See your medical team for routine physicals, wellness checks, diagnostic testing (colonoscopies...)
Some of it is genetics....your parents...
The rest, well, it's a crapshoot..
Kevin
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5 Reactions@kujhawk1978
I agree 100% :
"Diet
Exercise
Managing stress
See your medical team for routine physicals, wellness checks, diagnostic testing (colonoscopies...)
Some of it is genetics....your parents...
The rest, well, it's a crapshoot.. "
PS: I also agree with your wife LOL ; ) I would take car crash death over airplane falling down any time lol lol XP
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3 Reactions@kujhawk1978 Yeah, you can only do so much and the rest is just luck
Phil
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2 Reactions