Evenity after Forteo Didn't Work?

Posted by bwaykm @bwaykm, Mar 7 10:37am

Becasue Forteo is similar to Evenity does that mean if I already tried Forteo and it didn;t work the Evenity won't work?

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@bwaykm they are not similar and work in very different ways. Forteo works via the parathyroid. Evenity inhibits sclerostin. There is apparently not a whole lot of data on Evenity after Forteo (or Tymlos) but I am doing it after Tymlos. Time will tell! You can do bone marker blood tests to monitor perhaps.

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Hi @bwaykm

Yes, you can follow Forteo with Evenity and still get good results. Attached is a nice chart for you.

That said, do you know why Forteo did not work for you? Have you cleared the secondary causes of osteoporosis? If not, get that done before you start Evenity or you might have the same issue.

Mike

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@michaellavacot

Hi @bwaykm

Yes, you can follow Forteo with Evenity and still get good results. Attached is a nice chart for you.

That said, do you know why Forteo did not work for you? Have you cleared the secondary causes of osteoporosis? If not, get that done before you start Evenity or you might have the same issue.

Mike

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Can you provide a source for this chart as WindyShores doctors say there have been no studies that they are aware of for Evenity after Tymlos.

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The source of the study in on the bottom of the slide. If you search it, you will find this trial https://www.sciencedirect.com/science/article/abs/pii/S1297319X21000919?via%3Dihub . Unfortunately, you would have to purchase the study to get all of the data.

I got the slide from a presentation that Dr. Michael McClung presented at the Amgen Symposium, 21st AMMOM
Santiago de Querétaro, August 19, 2022. Dr. McClung emailed it to me.

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@normahorn I have run into a couple of studies with Evenity after no treatment, after alendronate, Prolia and Forteo. Not sure why both my docs say there is no data. I am going to ask them! Evenity after Prolia had the lowest effect, as I remember.

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@michaellavacot

Hi @bwaykm

Yes, you can follow Forteo with Evenity and still get good results. Attached is a nice chart for you.

That said, do you know why Forteo did not work for you? Have you cleared the secondary causes of osteoporosis? If not, get that done before you start Evenity or you might have the same issue.

Mike

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Have you seen any data about Forteo after Evenity?

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@nwyatt

Have you seen any data about Forteo after Evenity?

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@nwyatt I have not see any studies on Forteo after Evenity, but I wasn't looking for them either 🙂

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@nwyatt

Have you seen any data about Forteo after Evenity?

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Not that I recall.

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@windyshores

@normahorn I have run into a couple of studies with Evenity after no treatment, after alendronate, Prolia and Forteo. Not sure why both my docs say there is no data. I am going to ask them! Evenity after Prolia had the lowest effect, as I remember.

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normahorn, essentially there is no data. 16 women in the teriparatide arm. There may be another chart in this study that shows that reveals no reduction in fracture risk if you follow denosumab with romosumab. Waving the flag of a paywalled clinical chart from an abstract without clarification is dangerously simplistic.

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I had barely any gains on Forteo. Currently I am on my 10th month of Evenity. I had my DEXA scan 2 days ago. I went from -5.2 to -4.7 in my spine. Not great but I'll take it. Dr is suggesting Prolia for a short time, then I don't know what I will transition to.

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