Edema/Pleural Effusion, rare but known Side Effect from Docetaxel

Apparently, edema is a less common, but known, side effect from Docetaxel, especially cumulatively - this was our experience. After round #4., during the heat, my hub noticed some ankle swelling. He had that in the past in the heat after being on feet a couple of times.

After Round#5, it got worse and it was noted at doctors appt pre infusion. He also started coughing more. But given that his PCa metastasis is lung-only, we suspected irritation and cough would be part of the deal. He also noticed his eyes watered like crazy. PA suggested drops for dry eye.

After Round #6, it was worse - to the point where we got compression socks…and cough got more frequent. And more leaking from eyes and nose. PA listened to his lungs pre-infusion and said they sounded good and said the loss of nasal hair impacts watery nose….

One month after finishing 6 rounds of Docetaxel + Carboplatin, we were scheduled for a follow-up PSMA PET and labs at the COE we have been returning to every 3 mos - it’s a distance. The scan showed ‘large bilateral pleural effusion’ and the images are wild - about 1/3 X 1/2 the lung volume is fluid and lungs are a bit collapsed (fluid is in the pleural sac surrounding). We presented with a fire to put out and he had a liter drained from each side.

Now we know about ‘capillary leak syndrome’ that can be a side effect of docetaxel. It’s rare, but sharing as rare happens to some. Prostate cancer is a real bugger. One thing I will forewarn about chemo - when you finish all rounds and you think you are done, there is recovery that they say takes 2 mos for every month of chemo. So ring that bell and then be patient!