Does Ozempic Cause Headaches and exhaustion?
I have only taken two injections of Ozempic - previously I was on Trulicity - and have tolerated it well, but unfortunately, insurance will not pay for it and forced me to change.
After my first inject, within hours I was exhausted feeling and had a headache. I blamed it mainly on the time change, as it was the day before. I stayed exhausted all week, until the day before my next injection. Still, I was blaming it on the time change.
Today I took my 2nd injection, and almost immediately, I got a severe headache, and so exhausted I had to go to bed. This was much worse than last week. Is this a normal side effect, and will it improve or continue to get worse?
Interested in more discussions like this? Go to the Diabetes & Endocrine System Support Group.
Connect

Yes I've experienced bad headaches then after a 3rd Injection they lessened. When I went up in dose to 1mg I had headache again but for just couple days. I experienced nausea too. No appetite. Things tasted different. Things I liked didn't appeal to me anymore. Drink lots of water 💧! That helped a lot plus Tylenol and I was taking a CVS generic brand of pepcid AC as I was having indigestion, I'd wake up and have indigestion. I did cut out coffee and I loved my coffee but it didn't appeal to me anymore. Gren tea was way better. Rest as needed and take care of yourself! I went from 186 of prednisone weight to now 156. 30 lbs in 4 months. But if I exercise more it'll go quicker. I was like you I was tired but then 3 days after injecting semaglutide I had a natural energy. I think the getting tired part is because you may like me be low on protein. That will show up in blood test. Pretty normal when your not eating as much and metabolizing food is slow. Good luck on your journey !! 😊😊
-
Like -
Helpful -
Hug
1 Reaction@vllymedtec Thank you for the encouragement. I will try the third injection.
@sandy56124 welcome to Mayo Clinic Connect. Don’t you hate it when insurance dictates our medical treatment? But “they” do hold the purse strings so…..
All meds have potential side effects so hopefully you can adjust to this as @vllymedtec did if that is what you are experiencing. If you continue to have difficulties you could ask your pharmacist &/or your prescribing medical provider. If all else fails there may be an alternative that insurance will allow and that you will tolerate better. @vllymedtec speaking of pharmacist, check to make sure there isn’t some unpleasant interaction between Ozempic and the generic Pepcid AC. I’ve heard that various GI upsets can be side effects of Ozempic.