Statin discontinued due to neuropathy. What are some alternatives?

Posted by Nazir Khan @nukhan, Jan 19, 2020

I have been using Lipitor since 2007 for lowering my cholesterol which is on the list of those medicines that are suspected to cause neuropathy. I am thinking of discontinuing this menace but before doing so want to check with those members who have discontinued using statin and what is their experience. What alternative methods have they since adopted for lowering their cholesterol .. diet, alternative medication, exercise or anything else ?

Interested in more discussions like this? Go to the Neuropathy Support Group.

Profile picture for joelfritzler @joelfritzler

I’d been taking 20 mg. of Rosuvastatin a day for about a year before being diagnosed with neuropathy and I haven’t noticed any ill effects since I started taking gabapentin.

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Unfortunately there does seem to be a clear cut association between statins and neuropathy. The medical community continues to push statins as hard as they can, and if you raise the subject of neuropathy they will form a cross with there fingers. And run backwards.

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Profile picture for oceanlady22 @oceanlady22

I am suffering from CIPN I swear a lot of the pain is also caused by the 40 mg ( I cut the 80mg in half. ) I am so tired of doctors making me feel worse.

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I’d been taking 20 mg. of Rosuvastatin a day for about a year before being diagnosed with neuropathy and I haven’t noticed any ill effects since I started taking gabapentin.

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Profile picture for kenc @kenc

When I addressed this situation to my doctor, he said the low dose statins are relatively safe.

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I was just put on repatha an injection every two weeks Not a statin but still my muscles ache.

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Profile picture for writerbroad @writerbroad

I googled 'citrus bergamot research' and came up with a long list of studies done on the citrus bergamot essential oil. One of them was a study of adding the oil to chicken feed, and the yolk of those chickens' eggs had a markedly reduced amount of cholesterol and the shell was stronger. I was surprised that no human studies showed up and no studies on the supplement in pill form. My son in Australia has been using the citrus bergamot for years on the advice of his physician, who was involved in some sort of research. My own experience has been a marked reduction in triglycerides and increase in "good" cholesterol. The reduction in "bad" cholesterol was not as significant.

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Thank you very much for this information. I’m on an immunosuppressant med that raises my cholesterol. Similar to you, I don’t do meat, white flour, or refined sugars, and I try to walk at least two hours a day. But, nothing has helped. I’ll try the citrus bergamot!

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I tried all of those things to reduce my cholesterol, and they all worked. I started with taking Citrus Bergamot, which improved my numbers. I have been very good about my diet for years, but I decided to cut red meat and anything made with white flour. Again, my numbers improved. The biggest improvement occurred when my son asked me to take care of his dog while his family was traveling for several months. I took her for two long daily walks and two short ones. That produced the greatest positive change of all. I am currently using more olive oil, since I read that it is rich in polyphenols (as is the Citrus Bergamot) and is featured in the Mediterranean Diet that is the only diet that consistently shows up as a star among healthy diets. I should also mention that I am sugar sensitive (though my tests are always normal) and as I aged, I would get hangover-type symptoms every time I had a piece of cake or any sugary dessert. So I have avoided sugar for years. Something that is well known in the medical community, but never mentioned on cooking shows, is that sugar is the biggest cause of inflammation, which in turn is a cause for heart disease. A side effect of banishing sugar is that the arthritis, that had just begun to appear in my fingers, completely disappeared.

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Profile picture for Sue, Volunteer Mentor @sueinmn

Can you provide any medical or research studies about either of these products? All I see are promos by the sellers. My doc is pushing statins and I'm resisting.

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I googled 'citrus bergamot research' and came up with a long list of studies done on the citrus bergamot essential oil. One of them was a study of adding the oil to chicken feed, and the yolk of those chickens' eggs had a markedly reduced amount of cholesterol and the shell was stronger. I was surprised that no human studies showed up and no studies on the supplement in pill form. My son in Australia has been using the citrus bergamot for years on the advice of his physician, who was involved in some sort of research. My own experience has been a marked reduction in triglycerides and increase in "good" cholesterol. The reduction in "bad" cholesterol was not as significant.

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I stopped taking rosuvaststin . I was told by my cardiologist that it caused my neuropathy.

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Profile picture for Sue, Volunteer Mentor @sueinmn

Can you provide any medical or research studies about either of these products? All I see are promos by the sellers. My doc is pushing statins and I'm resisting.

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I’m sorry…no. I judged the products based on my own research and Amazon reviews. I’ll have my cholesterol rechecked in a few months. Im using Citrus Bergamot, which lowers cholesterol and so far my blood pressure has dropped significantly.

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Profile picture for Colleen Young, Connect Director @colleenyoung

@lvnv89131, You will be able to add URLs to your posts in a few days. There is a brief period where new members can't post links. We do this to deter spammers and keep the community safe. Clearly the links you wanted to post are not spam. Please allow me to post them for you.

Research related to plant sterols and stanols and policosanol for reducing cholesterol and LDL:
- LDL-Cholesterol Lowering of Plant Sterols and Stanols—Which Factors Influence Their Efficacy? (2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163911/
- Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels (2003) https://pubmed.ncbi.nlm.nih.gov/12911045/
- Plant sterols/stanols as cholesterol lowering agents: A meta-analysis of randomized controlled trials (2008) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596710/
- Effects of policosanol 20 versus 40 mg/day in the treatment of patients with type II hypercholesterolemia: a 6-month double-blind study (2001) https://pubmed.ncbi.nlm.nih.gov/11708574/
- Effects of policosanol on older patients with hypertension and type II hypercholesterolaemia (2002) https://pubmed.ncbi.nlm.nih.gov/12099160/

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Thank you so much for your explanation regarding links as well as for posting them. Although I was using the sterols/stanols and almost ready to begin with the policosanol, I'm now focusing my attention more on Sytrinol which seems to have more unanimous support and reproducible results with less side effects although the previously mentioned had few. Sytrinol is also very similar to the Citrus Bergamot many have mentioned but appears to be more specific acting with less dosage and potential side effects, at least from my research. I later found that there was some debate but not completely dismissive of the policosanol as it seemed to mostly if not solely be based on Cuban Trials which seemed not being able to be reproduced by others and also there's some debate as to the whether policosanol has to be solely sourced from sugar cane wax or can be obtained from insects or rice sources? I've also found substantial information regarding the effectiveness of pantethine, the more refined version of Vitamin B5 pantothenic acid and it's broad spectrum reduction of cholesterol as well as it's role in the balance and regulation of cortisol and adrenaline which I also believe is significant in my issues with palpitations and adrenaline type rushes. I may add the policosanol into the Sytrinol regimen after giving it some time to verify the results of cholesterol values for possible synergistic/additive reduction.

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Profile picture for lvnv89131 @lvnv89131

I Had some links with data containing Medical/Scientific research on plant sterols and stanols and Policosanol for reducing cholesterol and LDL as an alternative to statins but as a new member I couldn't post them or send them to anyone who can, already tried. What I'll briefly share should you do your own research on those topics and see controversial findings is that it should be known that in this instance the supplemental forms are better than whole food or enriched food forms on which there is some debate and there is information as well as to the possible best times to take them to coincide with when the body's internal clock processes cholesterol. All three of those supplements are also useful in making statins that much more effective when combined with them or possibly using a lower dose of statins with these supplements taking up the slack.

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@lvnv89131, You will be able to add URLs to your posts in a few days. There is a brief period where new members can't post links. We do this to deter spammers and keep the community safe. Clearly the links you wanted to post are not spam. Please allow me to post them for you.

Research related to plant sterols and stanols and policosanol for reducing cholesterol and LDL:
- LDL-Cholesterol Lowering of Plant Sterols and Stanols—Which Factors Influence Their Efficacy? (2018) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163911/
- Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels (2003) https://pubmed.ncbi.nlm.nih.gov/12911045/
- Plant sterols/stanols as cholesterol lowering agents: A meta-analysis of randomized controlled trials (2008) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596710/
- Effects of policosanol 20 versus 40 mg/day in the treatment of patients with type II hypercholesterolemia: a 6-month double-blind study (2001) https://pubmed.ncbi.nlm.nih.gov/11708574/
- Effects of policosanol on older patients with hypertension and type II hypercholesterolaemia (2002) https://pubmed.ncbi.nlm.nih.gov/12099160/

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